Konjac oligosaccharides attenuate DSS-induced ulcerative colitis in mice: mechanistic insights

Xia, Pengkui; Hou, Tao; Ma, Mu-yuan; Li, Sha; Jin, Honglin; Luo, Xuan; Li, Jing; Geng, Fang; Li, Bin

doi:10.1039/d1fo04004a

Cited by 13 publications

(8 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bifidobacteriaceae have shown beneficial effects in an animal, such as promoting nutrient absorption and improving immunity ( 71 ). Akkermansiaceae belong to the phylum Verrucomicrobia and are considered anti-inflammatory bacteria ( 72 ). The abundance of Akkermansiaceae is negatively correlated with obesity, which in turn promotes the occurrence of inflammatory diseases ( 73 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary supplementation with dandelion tannins or soybean isoflavones on growth performance, antioxidant function, intestinal morphology, and microbiota composition in Wenchang chickens

Sun

Liu

et al. 2023

Front. Vet. Sci.

View full text Add to dashboard Cite

Many benefits have been found in supplementing tannins or soybean isoflavones to poultry, including increased body weight gain, antioxidant activity, and better intestinal morphology. However, few studies tested the influence of dandelion tannins or soybean isoflavones supplementation on Wenchang chickens. This study investigates the effects of dietary supplementation with dandelion tannins or soybean isoflavones on the growth performance, antioxidant function, and intestinal health of female Wenchang chickens. A total of 300 chickens were randomly divided into five groups, with six replicates per group and 10 broilers per replicate. The chickens in the control group (Con) were fed a basal diet; the four experimental groups were fed a basal diet with different supplements: 300 mg/kg of dandelion tannin (DT1), 500 mg/kg of dandelion tannin (DT2), 300 mg/kg of soybean isoflavone (SI1), or 500 mg/kg of soybean isoflavone (SI2). The experiment lasted 40 days. The results showed that the final body weight (BW) and average daily gain (ADG) were higher in the DT2 and SI1 groups than in the Con group (P < 0.05). In addition, dietary supplementation with dandelion tannin or soybean isoflavone increased the level of serum albumin (P <0.05); the concentrations of serum aspartate aminotransferase and glucose were significantly higher in the SI1 group (P < 0.05) than in the Con group and the concentration of triglycerides in the DT1 group (P < 0.05). The serum catalase (CAT) level was higher in the DT1 and SI1 groups than in the Con group (P < 0.05). The ileum pH value was lower in the DT2 or SI1 group than in the Con group (P < 0.05). The jejunum villus height and mucosal muscularis thickness were increased in the DT2 and SI1 groups (P < 0.05), whereas the jejunum crypt depth was decreased in the DT1 or DT2 group compared to the Con group (P < 0.05). In addition, the messenger RNA (mRNA) expression level of zonula occludens 1 (ZO-1) in the duodenum of the SI1 group and those of occludin, ZO-1, and claudin-1 in the ileum of the DT2 and SI1 groups were upregulated (P < 0.05) compared to the Con group. Moreover, the DT2 and SI1 groups exhibited reduced intestinal microbiota diversity relative to the Con group, as evidenced by decreased Simpson and Shannon indexes. Compared to the Con group, the relative abundance of Proteobacteria was lower and that of Barnesiella was higher in the DT2 group (P < 0.05). Overall, dietary supplementation with 500 mg/kg of dandelion tannin or 300 mg/kg of soybean isoflavone improved the growth performance, serum biochemical indexes, antioxidant function, and intestinal morphology and modulated the cecal microbiota composition of Wenchang chickens.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of dietary supplementation with dandelion tannins or soybean isoflavones on growth performance, antioxidant function, intestinal morphology, and microbiota composition in Wenchang chickens

Sun

Liu

et al. 2023

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…The shortening of the colon and increased mass of the colon per unit length are generally considered important pathological features of UC. 51 All treatments had positive effects on increasing colon length and decreasing colon density, while L-SOD treatment decreased colon density most significantly. Generally, impaired intestinal barrier functions in UC patients lead to the increased permeability of the intestinal mucosa to LPS and antigens, ultimately leading to the increased expression of the NF-κB pathway and pro-inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 87%

Liposome-embedded SOD attenuated DSS-induced ulcerative colitis in mice by ameliorating oxidative stress and intestinal barrier dysfunction

Zhang

Yuan

et al. 2023

Food Funct.

View full text Add to dashboard Cite

show abstract

“…Mice in the control group were given free access to sterile water, whereas mice in the other groups were given free access to 3% DSS solution (replaced every two days) for 8 days to develop acute experimental colitis. Groups were respectively given intragastric administration with normal saline, 200 mg/kg SASP [ 14 , 15 ], 500 mg/kg JJSM and 1000 mg/kg JJSM [ 16 ] for 8 days. The body weight, softness of feces and anal bleeding of the mice were recorded, and the drug intervention was observed after daily intragastric administration.…”

Section: Methodsmentioning

confidence: 99%

Gas-Mediated Intestinal Microbiome Regulation Prompts the Methanol Extract of Schizonepetae Spica to Relieve Colitis

Cen

et al. 2023

Nutrients

View full text Add to dashboard Cite

Intestinal dysbiosis plays an important role in the pathogenesis of colitis (UC). Schizonepetae Herba can achieve anti-inflammatory effects as a medicine and food homologous vegetable. Luteolin, eriodictyol, fisetin, and kaempferol are the main anti-inflammatory active compounds obtained through mass spectrometry from the methanol extract of Schizonepetae Spica (JJSM). JJSM intervention resulted in attenuated weight loss, high disease-activity-index score, colon length shortening and colonic pathological damage in DSS-induced colitis mice. Interestingly, hydrogen sulfide (H2S) was inhibited remarkably, which is helpful to elucidate the relationship between active substance and intestinal flora. Furthermore, JJSM administration improved intestinal flora with down-regulating the abundance of harmful bacteria such as Clostridiales and Desulfovibrio and up-regulating the abundance of beneficial bacteria such as Muribaculaceae and Ligolactobacillus and enhanced the production of SCFAs. It is worth noticing that Desulfovibrio is related to the production of intestinal gas H2S. The elevated levels of Desulfovibrio and H2S will hasten the onset of colitis, which is a crucial risk factor for colitis. The results displayed that JJSM could considerably ameliorate colitis by rebuilding H2S-related intestinal flora, which provides a new therapeutic strategy for Schizonepetae Spica to be utilized as a functional food and considered as an emerging candidate for intestinal inflammation.

show abstract

Konjac oligosaccharides attenuate DSS-induced ulcerative colitis in mice: mechanistic insights

Abstract: This study is aimed to explore the protective effect of konjac oligosaccharides (KOS) on inflammatory bowel disease in colitis mice. During the experimental period, colitis mice were administered with 200mg/kg...

Cited by 13 publications

References 61 publications

Effects of dietary supplementation with dandelion tannins or soybean isoflavones on growth performance, antioxidant function, intestinal morphology, and microbiota composition in Wenchang chickens

Effects of dietary supplementation with dandelion tannins or soybean isoflavones on growth performance, antioxidant function, intestinal morphology, and microbiota composition in Wenchang chickens

Liposome-embedded SOD attenuated DSS-induced ulcerative colitis in mice by ameliorating oxidative stress and intestinal barrier dysfunction

Gas-Mediated Intestinal Microbiome Regulation Prompts the Methanol Extract of Schizonepetae Spica to Relieve Colitis

Contact Info

Product

Resources

About