-Many previous studies investigate the effect, process and the performance of innovation. However, the relationship between human capital (HC), social capital (SC), and innovation outcome is still limited. Therefore, this paper aims to present a systematic literature review on identifying the relationship between HC, SC, and innovation outcome over the past three decades . This review also identifies the gaps and future agenda. From 43 relevant papers, we find positive and negative effect of HC and SC to innovation. As well as, we identify the knowledge management orientation, entrepreneurial orientation and culture orientation as the driver of innovation outcome. Finally, we construct the conceptual framework that would be a starting point of strategy development in innovation management to attain the competitive advantage.