Knowledge and Attitudes About Breast Cancer in Limpopo, South Africa

Trupe, Lydia A.; Rositch, Anne F.; Dickerson, Lindsay K.; Lucas, Su; Harvey, Susan C.

doi:10.1200/jgo.2016.008102

Cited by 10 publications

(12 citation statements)

References 9 publications

(7 reference statements)

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“…It should be noted that in the general women population, educational level in Niger is not that much heterogenous, in our sample only 5.5% had higher education. Trupe et al, 2017 in a study in Limpopo, South Africa, could not find an association nor between educational level neither between age on the one hand and breast cancer awareness on the other hand. Nevertheless, some studies established an association between breast cancer awareness and educational level in sub Saharan African context in Nigeria (Okobia et al, 2006) and in Ghana (Opoku, 2012).…”

Section: Discussionmentioning

confidence: 80%

Awareness, attitudes and practices of women in relation to breast cancer in Niger

Abdou

Hal

Dille

2020

Heliyon

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Introduction: In Niger, breast cancer is the first cancer related morbidity and mortality within female population. While awareness can contribute to early diagnosis and disease mortality reduction, Niger women's knowledge of breast cancer is not well documented. In this study, we assessed the awareness, attitudes and practices of women in relation to breast cancer and identify the factors associated with it. Methods: The study was conducted through a cross sectional survey in Zinder and Niamey regions. A random sampling was used to select women in households within health districts. We defined a breast cancer knowledge score and used a generalized linear model to assess factors associated with it. Results: Overall women's knowledge of breast cancer was found to be low, only 41.2% (37.5-45.0) were aware of breast cancer. 65.0% (61.3-68.7) of women demonstrated an awareness of symptoms. Insufficient level of knowledge was observed on knowledge of risk and protection factors with 27.4 % (24.0-31.0), breast cancer good practice with 16.9% (14.2-19.7). Age OR ¼ 0.98 (0.96-0.99), practicing clinical breast examination OR ¼ 2.25 (1.31-3.16), breastfeeding 3.34 (2.12-5.26), not having a history of participation in breast cancer screening and living in rural and peri-urban areas were found to be associated with awareness of breast cancer. Conclusion: Niger women were found to have a relatively low level of breast cancer awareness. While not acquainted with self and clinical breast examination, Niger women knowledge of breast cancer symptoms was acceptable. Awareness programs can promote clinical breast examination as mammography is not common and promote early detection procedures.

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Section: Discussionmentioning

confidence: 80%

Awareness, attitudes and practices of women in relation to breast cancer in Niger

Abdou

Hal

Dille

2020

Heliyon

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“…Participants who answer less than 50% of the knowledge questions were considered as having poor knowledge. Similarly, participants who answer 50–75% and greater than 75% were also classified as having medium and good knowledge about BSE, respectively [15]. Furthermore, participant's practices of BSE were determined from binary outcome variable (yes, no).…”

Section: Methodsmentioning

confidence: 99%

Practices of Breast Self-Examination and Associated Factors among Female Debre Berhan University Students

Birhane

Alemayehu

Anawte

et al. 2017

International Journal of Breast Cancer

103

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Background Breast cancer is the most prevalent form of cancer in Ethiopia of all female cancers. It is considered to be a progressive disease with a poor prognosis if detected late. Breast self-examination is an important prevention method of breast cancer. This study was aimed at assessing practice and associated factors of breast self-examination (BSE) among female Debre Berhan University students in Ethiopia. Methods A cross-sectional study was conducted in 2015 among 420 using self-administrated questionnaire. Multistage sampling technique was used to select the study participants. Bivariate and multivariate logistic regression analysis were done. Results Majority of the study participants, 338 (84.5%), were between 20 and 24 years old with the mean age of 21.1 ± 1.65. Only 14 (3.5%) had family history of breast cancer. Two hundred fifty-six (64%) of the participants had heard about BSE and 30.25% had good knowledge about BSE. Mass media were the most common source of information about breast cancer. Few of the participants (28.3%) had performed BSE. Lack of knowledge on how to perform BSE was cited as the main reason for not practicing BSE. Knowing how to perform, when to perform, and position to perform BSE and having a perception that BSE is important and useful to detect breast cancer were significant predictors of practices of BSE. Conclusions This study revealed that most of the participants had low knowledge and practice of BSE. Therefore, it important to develop health educational programs in the university to raise awareness about BSE and breast cancer so as to practice self-breast examination.

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“…Sample collection using buccal swabs for POC DNA testing could replace the more expensive (ZAR 2 508.54) laboratory-based founder variant detection assay once fully validated against confirmed positive and negative controls. Such a rapid screen may increase access into the right care pathway as the average South African female has very limited knowledge regarding potential risk factors, although most are aware that a breast or lump in the armpit could be a sign of disease ( 55 , 56 ). As both the two-gene assay and the multigene test are currently offered at the same price (ZAR 7 912.86), the expanded test will be more beneficial for patients, even though costly poly (ADP-ribose) inhibitors are not yet available to mutation carriers in the public sector.…”

Section: Discussionmentioning

confidence: 99%

Implementation of multigene panel testing for breast and ovarian cancer in South Africa: A step towards excellence in oncology for the public sector

et al. 2022

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Translation of genomic knowledge into public health benefits requires the implementation of evidence-based recommendations in clinical practice. In this study, we moved beyond BRCA1/2 susceptibility testing in breast and ovarian cancer patients to explore the application of pharmacogenetics across multiple genes participating in homologous recombination DNA damage repair. This involved the utilisation of next-generation sequencing (NGS) at the intersection of research and service delivery for development of a comprehensive genetic testing platform in South Africa. Lack of international consensus regarding risk categorization of established cancer susceptibility genes and the level of evidence required for prediction of drug response supported the development of a central database to facilitate clinical interpretation. Here we demonstrate the value of this approach using NGS to 1) determine the variant spectrum applicable to targeted therapy and implementation of prevention strategies using the 15-gene Oncomine™ BRCA Expanded Panel, and 2) searched for novel and known pathogenic variants in uninformative cases using whole exome sequencing (WES). Targeted NGS performed as a routine clinical service in 414 South African breast and/or ovarian cancer patients resulted in the detection of 48 actionable variants among 319 (15%) cases. BRCA1/2-associated cancers were identified in 70.8% of patients (34/48, including two double-heterozygotes), with the majority (35.3%, 12/34) representing known South African founder variants. Detection of actionable variants in established non-BRCA1/2 risk genes contributed 29% to the total percentage (14/48), distributed amongst ATM, CHEK2, BARD1, BRIP1, PALB2 and TP53. Experimental WES using a virtually constructed multi-cancer NGS panel in 16 genetically unresolved cases (and four controls) revealed novel protein truncating variants in the basal cell carcinoma gene PTCH1 (c.4187delG) and the signal transmission and transduction gene KIT (c.930delA) involved in crucial cellular processes. Based on these findings, the most cost-effective approach would be to perform BRCA1/2 founder variant testing at referral, followed by targeted multigene panel testing if clinically indicated and addition of WES in unresolved cases. This inventive step provides a constant flow of new knowledge into the diagnostic platform via a uniquely South African pathology-supported genetic approach implemented for the first time in this context to integrate research with service delivery.

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Knowledge and Attitudes About Breast Cancer in Limpopo, South Africa

Cited by 10 publications

References 9 publications

Awareness, attitudes and practices of women in relation to breast cancer in Niger

Awareness, attitudes and practices of women in relation to breast cancer in Niger

Practices of Breast Self-Examination and Associated Factors among Female Debre Berhan University Students

Implementation of multigene panel testing for breast and ovarian cancer in South Africa: A step towards excellence in oncology for the public sector

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