Know Your Heart: Rationale, design and conduct of a cross-sectional study of cardiovascular structure, function and risk factors in 4500 men and women aged 35-69 years from two Russian cities, 2015-18

Cook, Sarah; Malyutina, Sofia; Kudryavtsev, Alexander; Averina, Maria; Bobrova, Natalia; Boytsov, S. А.; Brage, Sören; Clark, Taane G.; Benavente, Ernest Diez; Eggen, Anne Elise; Hopstock, Laila Arnesdatter; Hughes, Alun D.; Johansen, Heidi; Холматова, К К; Kichigina, Anastasiya; Kontsevaya, A. V.; Kornev, Michael; Leong, Darryl P.; Magnus, Per; Mathiesen, Ellisiv B.; McKee, Martin; Morgan, Katy E; Nilssen, Odd; Plakhov, Ilya; Quint, Jennifer K; Rapala, Alicja; Ryabikov, Andrey; Saburova, Lyudmila; Schirmer, Henrik; Shapkina, Marina; Shiekh, Suhail; Shkolnikov, Vladimir M.; Stylidis, Michael; Воевода, М. И.; Westgate, Kate; Leon, David A.

doi:10.12688/wellcomeopenres.14619.2

Cited by 25 publications

(7 citation statements)

References 44 publications

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“…Связи вчСРБ и маркеров СН были изучены у участ ников исследования «Узнай свое сердце» (далее -УСС), проведенного в 2015-2017 гг. с использованием случай ной выборки из общего населения четырех округов г. Ар хангельска в возрасте от 35 до 69 лет [16]. Письменное информированное согласие получено от всех участни ков.…”

Section: материал и методыunclassified

“…Доля мужчин -41,5 %. Спо соб формирования выборки и ее характеристики опи саны ранее [16]. У 2 356 участников УСС был опреде лен уровень вчСРБ.…”

Section: дизайн исследования и обследуемыеunclassified

“…Используемые данные о наличии у участников иссле дования сахарного диабета, артериальной гипертензии, СН и перенесенного инфаркта миокарда, а также данные о курении получены со слов респондентов посредством устного сбора анамнестических данных с использовани ем стандартизированного опросника, представленного в приложениях к публикации S. Cook и соавт. [16].…”

Section: анамнестические данныеunclassified

“…Методика забора образцов описана [16]. Уровни вчСРБ и цистатина С в сыворотке и HbA 1c в цельной кро ви (EDTA) были определены иммуннотурбидиметри ческим методом (AU 680; Chemistry System Beckman Coulter).…”

Section: лабораторные измеренияunclassified

“…Эхокардиографические (ЭхоКГ) исследования вы полнены на ультразвуковом аппарате GE VividQ (GE Health care) в соответствии со стандартным ЭхоКГ про токолом УСС [16]. Систолическая функция ЛЖ бы ла определена по фракции выброса (ФВ), рассчитанной по методу Simpson.…”

Section: эхокардиографическое исследованиеunclassified

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C-reactive protein and its associations with сardiometabolic risk factors and echocardiographic indicators of heart failure: results of “Know your heart” study in Arkhangelsk

et al. 2020

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Aim To evaluate the relationship between high-sensitivity C-reactive protein (hsCRP) and echocardiographic (EchoCG) indicators of heart failure (HF) among adult population of the North region of Russia.Material and methods The Know Your Heart transversal study was performed in 2015–2017 on a random sample of adult population of Arkhangelsk aged 35–69 years (n=2381). The exclusion criterion for this study was a concentration of hsCRP >10 mg/l. The group of subclinical inflammation included 686 participants with hsCRP ≥2.0 mg/l; the comparison group consisted of 1158 participants with hsCRP <2.0 mg/l. Analysis included cardiometabolic risk factors, EchoCG indexes of left ventricular (LV) systolic and diastolic function and biomarkers (NT-proBNP, hsTroponin Т, cystatin С). Linear and logistic regressions were used.Results The group with hsCRP ≥2.0 mg/l had higher rates of arterial hypertension, diabetes mellitus, HF, and myocardial infarction in history than the comparison group. The hsCRP level was independently associated with waist circumference (β=0.379, p <0.001), male gender (β=–0.135, p<0.001), smoking (β=0.109, p<0.001), triglycerides (β=0.083, p<0.001), diastolic blood pressure (β=0.082, p<0.001), cystatin C (β=0.082, p<0.001), glycated hemoglobin (β=0.064, p=0.003), and low-density lipoproteins (LDL) (β=0.049, p=0.025). Independent predictors of subclinical inflammation included older age, smoking, abdominal obesity, elevated values of LDL (>3.0 mmol/l), triglycerides (>1.7 mmol/l), and cystatin C (>1.2 mg/l). hsCRP was independently negatively associated with LV ejection fraction, left atrial volume index, ratio of early to late LV diastolic filling velocity (p=0.003, p=0.002, p=0.005, respectively), which reflected the relationship of the increased content of hsCRP with impairment of LV systolic and diastolic function. A relationship between heart remodeling indexes and hsCRP concentration was shown.Conclusion In a sample of adult population from the North region of Russia, the hsCRP concentration was independently associated with cardiometabolic risk factors and structural and functional changes in the heart detected by EchoCG, which reflects a potential contribution of inflammation to heart remodeling and development of HF.

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Section: материал и методыunclassified

Section: дизайн исследования и обследуемыеunclassified

Section: анамнестические данныеunclassified

Section: лабораторные измеренияunclassified

Section: эхокардиографическое исследованиеunclassified

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C-reactive protein and its associations with сardiometabolic risk factors and echocardiographic indicators of heart failure: results of “Know your heart” study in Arkhangelsk

et al. 2020

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Between‐study differences in grip strength: a comparison of Norwegian and Russian adults aged 40–69 years

Cooper

Shkolnikov

Kudryavtsev

et al. 2021

J cachexia sarcopenia muscle

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Background Identifying individuals with low grip strength is an initial step in many operational definitions of sarcopenia. As evidence indicates that contemporaneous Russian populations may have lower mean levels of grip strength than other populations in northern Europe, we aimed to: compare grip strength in Russian and Norwegian populations by age and sex; investigate whether height, body mass index, education, smoking status, alcohol use and health status explain observed differences and; examine implications for case‐finding low muscle strength. Methods We used harmonized cross‐sectional data on grip strength and covariates for participants aged 40–69 years from the Russian Know Your Heart study (KYH) (n = 3833) and the seventh survey of the Norwegian Tromsø Study (n = 5598). Maximum grip strength (kg) was assessed using the same protocol and device in both studies. Grip strength by age, sex and study was modelled using linear regression and between‐study differences were predicted from these models. Sex‐specific age‐standardized differences in grip strength and in prevalence of low muscle strength were estimated using the European population standard of 2013. Results Normal ranges of maximum grip strength in both studies combined were 33.8 to 67.0 kg in men and 18.7 to 40.1 kg in women. Mean grip strength was higher among Tromsø than KYH study participants and this difference did not vary markedly by age or sex. Adjustment for covariates, most notably height, attenuated between‐study differences but these differences were still evident at younger ages. For example, estimated between‐study differences in mean grip strength in fully adjusted models were 2.2 kg [95% confidence interval (CI) 1.4, 3.1] at 40 years and 1.0 kg (95% CI 0.5, 1.5) at 65 years in men (age × study interaction P = 0.09) and 1.1 kg (95% CI 0.4, 1.9) at age 40 years and −0.2 kg (95% CI −0.7, 0.3) at 65 years in women (age × study interaction P < 0.01). Conclusions We found between‐study differences in mean grip strength that are likely to translate into greater future risk of sarcopenia and poorer prospects of healthy ageing for Russian than Norwegian study participants. For example, the average Russian participant had a similar level of grip strength to a Norwegian participant 7 years older. Our findings suggest these differences may have their origins in childhood highlighting the need to consider interventions in early life to prevent sarcopenia.

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Global myocardial longitudinal strain in a general population—associations with blood pressure and subclinical heart failure: The Tromsø Study

Stylidis

Leon

Røsner

et al. 2019

Int J Cardiovasc Imaging

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The early detection of subclinical myocardial dysfunction can contribute to the treatment and prevention of heart failure (HF). The aim of the study was to (i) describe myocardial global longitudinal strain (GLS) patterns in a large general population sample from Norway and their relation to established cardiovascular disease (CVD) risk factors; (ii) to determine its normal thresholds in healthy individuals and (iii) ascertain the relation of myocardial GLS to stage A subclinical heart failure (SAHF). Methods: Participants (n=1855) of the 7 th survey of the population-based Tromsø Study of Norway (2015-2016) with GLS measurements were studied. Linear and logistic regression models were used for assessment of the associations between CVD risk factors and GLS. Results: Mean GLS (SD) in healthy participants was-15.9 (2.7)% in men and-17.8 (3.1)% in women. Among healthy subjects, defined as those without known cardiovascular diseases and comorbidities, GLS declined with age. An increase of systolic blood pressure (SBP) of 10 mm Hg was associated with a 0.2% GLS reduction. Myocardial GLS in individuals with SAHF was 1.2% lower than in participants without SAHF (p<0.001). Conclusion: Mean myocardial GLS declines with age in both sexes, both in a general population and in the healthy subsample. SBP increase associated with GLS decline in women. Our findings indicate high sensitivity of GLS for early subclinical stages of HF.

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Know Your Heart: Rationale, design and conduct of a cross-sectional study of cardiovascular structure, function and risk factors in 4500 men and women aged 35-69 years from two Russian cities, 2015-18

Cited by 25 publications

References 44 publications

C-reactive protein and its associations with сardiometabolic risk factors and echocardiographic indicators of heart failure: results of “Know your heart” study in Arkhangelsk

C-reactive protein and its associations with сardiometabolic risk factors and echocardiographic indicators of heart failure: results of “Know your heart” study in Arkhangelsk

Between‐study differences in grip strength: a comparison of Norwegian and Russian adults aged 40–69 years

Global myocardial longitudinal strain in a general population—associations with blood pressure and subclinical heart failure: The Tromsø Study

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