2020
DOI: 10.21203/rs.3.rs-19098/v1
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Abstract: Background Liver cancer is a frequent malignancy with poor prognosis. It has been reported that many lncRNAs could regulate the progression of liver cancer. To identify potential therapeutic targets for liver cancer, we conducted bioinformatics analysis of lncRNAs in tumor tissues and adjacent normal tissues. Methods The differential expression of lncRNAs between liver cancer tissues and adjacent normal tissues were examined by bioinformatics analysis. Cell proliferation was tested by CCK-8. Cell apoptosis in … Show more

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Cited by 4 publications
(4 citation statements)
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“…LINC01234, located on chromosome 12, plays an active role in several cancers. Suppression of LINC01234 expression was found to restrain liver cancer progression via the mediation of the miR-513a-5p/USP4/TGF-β axis [32]. LINC01234 was also shown to regulate the progression of clear cell renal cell carcinoma cells by HIF-2a pathways…”
Section: Discussionmentioning
confidence: 96%
“…LINC01234, located on chromosome 12, plays an active role in several cancers. Suppression of LINC01234 expression was found to restrain liver cancer progression via the mediation of the miR-513a-5p/USP4/TGF-β axis [32]. LINC01234 was also shown to regulate the progression of clear cell renal cell carcinoma cells by HIF-2a pathways…”
Section: Discussionmentioning
confidence: 96%
“…MicroRNAs (miRNAs) are a class of endogenous small RNAs of approximately 20-23 nucleotides in length [34] that play important roles in regulating tumor cell proliferation, migration and invasion [35]. MiR-513a-5p was reported to play antitumor roles in gastric cancer, liver cancer, renal cell carcinoma and BCa [21,[36][37][38][39]. qRT-PCR results showed that the level of miR-513a-5p was downregulated in BCa cell lines.…”
Section: Discussionmentioning
confidence: 99%
“…MicroRNA-513a-5p (miR-513a-5p) is related to the multidrug resistance of retinoblastoma [11] and can reduce chemosensitivity of glioma to temozolomide through targeting NEDD4L [12]. Xu et al [13] stated that miR-513a-5p inhibited cell malignant behaviors in liver cancer. AMPK-Related Protein Kinase 5 (ARK5) is a downstream molecule of the Akt signalling pathway.…”
Section: Introductionmentioning
confidence: 99%
“…Xu et al . [13] stated that miR-513a-5p inhibited cell malignant behaviors in liver cancer. AMPK-Related Protein Kinase 5 (ARK5) is a downstream molecule of the Akt signalling pathway.…”
Section: Introductionmentioning
confidence: 99%