Knockdown of lncRNA LINC01234 Suppresses the Tumorigenesis of Liver Cancer via Sponging miR-513a-5p

Xu, Wen; Li, Kesang; Song, Chen; Wang, Xiaotong; Li, Yueqi; Xu, Baixue; Liang, Xin; Deng, Wan-Li; Wang, Junqing; Liu, Jianwen

doi:10.3389/fonc.2020.571565

Cited by 20 publications

(10 citation statements)

References 46 publications

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“…This study identified the lncRNA features derived from genomic instability as an independent prognostic marker for stratifying the risk subgroups of renal cancer patients. Through further prospective verification, GlncScore may be of great significance to the genomic instability and customized decision-making of renal cancer patients [ 17 – 20 ].…”

Section: Discussionmentioning

confidence: 99%

The lncRNA Signatures of Genome Instability to Predict Survival in Patients with Renal Cancer

Huang

Xie

Jiang

et al. 2021

Journal of Healthcare Engineering

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Long noncoding RNAs (lncRNAs) exert an increasingly important effect on genome instability and the prognosis of cancer patients. The present research established a computational framework originating from the mutation assumption combining lncRNA expression profile and somatic mutation profile in the genome of renal cancer to assess the effect of lncRNAs on the gene instability of renal cancer. A total of 45 differentially expressed lncRNAs were evaluated to be genome-instability-associated from the high and low cumulative somatic mutations groups. Then we established a prognosis model based on three genome-instability-associated lncRNAs (AC156455.1, AC016405.3, and LINC01234)-GlncScore. The GlncScore was then verified in testing cohort and the total TCGA renal cancer cohort. The GlncScore was evaluated to have an accurate prediction for the survival of patients. Furthermore, GlncScore was associated with somatic mutation patterns, indicating its capacity of reflecting genome instability in renal cancer. In conclusion, this study evaluated the effect of lncRNAs on genome instability of renal cancer and provided new hidden cancer biomarkers related to genome instability in renal cancer.

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Section: Discussionmentioning

confidence: 99%

The lncRNA Signatures of Genome Instability to Predict Survival in Patients with Renal Cancer

Huang

Xie

Jiang

et al. 2021

Journal of Healthcare Engineering

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“…LINC01234, located on chromosome 12, plays an active role in several cancers. Suppression of LINC01234 expression was found to restrain liver cancer progression via the mediation of the miR-513a-5p/USP4/TGF- β axis [ 32 ]. LINC01234 was also shown to regulate the progression of clear cell renal cell carcinoma cells by HIF-2a pathways [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

LINC01234 Accelerates the Progression of Breast Cancer via the miR-525-5p/Cold Shock Domain-Containing E1 Axis

Zhang

et al. 2022

Disease Markers

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Backgrounds. Long noncoding RNAs (lncRNAs) are strongly associated with the development of breast cancer (BC). As yet, the function of LINC01234 in BC remains unknown. Methods. Using biological information, the potential lncRNA, miRNA, and target gene were predicted. LINC01234 and miR-525-5p expression in BC tissues was detected using quantitative real-time reverse transcription polymerase chain reaction. Fluorescence in situ hybridization was used to determine the distribution of LINC01234. Cell proliferation was analyzed using CCK-8 assay, colony formation, terminal deoxynucleotidyl transferase dUTP nick end labeling staining, and apoptosis evaluated using flow cytometry. Western blotting was used to evaluate protein expression. Dual-luciferase® reporter, RNA pull-down, and RNA immunoprecipitation assays were performed to analyze the binding relationships among LINC01234, miR-525-5p, and cold shock domain-containing E1 (CSDE1). Results. We screened out LINC01234, found to be significantly increased in BC tissues, associated with a poor prognosis, and positively correlated with tumor size of BC. Knockdown of LINC01234 suppressed BC cell growth and facilitated apoptosis. Dual-luciferase reporter®, RNA pull-down, and RNA immunoprecipitation assays confirmed that LINC01234 and CSDE1 directly interacted with miR-525-5p. Upregulation of miR-525-5p and suppression of CSDE1 inhibited BC cell growth and induced cell apoptosis. Conclusion. Upregulation of LINC01234 contributes to the development of BC through the miR-525-5p/CSDE1 axis. LINC01234 may be one of the potential diagnostic and treatment targets for BC.

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“…Several studies have shown that LINC01234 is closely associated with tumor cell proliferation and metastasis ( 27 – 29 ). LINC01234 has emerged as an important regulator that is upregulated in colon cancer and is associated with poor prognosis ( 30 ), and its knockdown significantly inhibitted tumorigenesis in hepatocellular carcinoma ( 31 ). In addition, mutational analysis showed that the high-risk group contained more mutations in cancer-related genes, such as TP53 and PIK3CA , which have been previously reported to be closely associated with cancer development ( 32 , 33 ).…”

Section: Discussionmentioning

confidence: 99%

Cancer-associated fibroblasts-derived lncRNA signature as a putative biomarker in breast cancer

Luo

2022

Front. Oncol.

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Long noncoding RNAs (lncRNAs) have been reported to play a key role in regulating tumor microenvironment and immunity. Cancer-associated fibroblasts (CAFs) are abundant in many tumors. However, the functional and clinical significance of lncRNAs specifically expressed in CAFs has not been fully elucidated. In this study, we identified a list of 95 CAF-specific lncRNAs (FibLnc), including HHLA3, TP53TG1, ST7-AS1, LINC00536, ZNF503-AS1, MIR22HG, and MAPT-AS1, based on immune cell transcriptome expression profiling data. Based on the Cancer Genome Atlas and Gene Expression Omnibus datasets, we found that the FibLnc score predicted differences in overall patient survival and performed well in multiple datasets. FibLnc score was associated with the clinical stage of patients with breast cancer but did not significantly correlate with the PAM50 classification. Functional analysis showed that FibLnc was positively correlated with signaling pathways associated with malignant tumor progression. In addition, FibLnc was positively correlated with tumor mutational load and could predict immunotherapy response in patients with breast cancer receiving anti-PD-1 or anti-CTLA4 therapy. Our proposed FibLnc score was able to reflect the status of the immune environment and immunotherapeutic response in breast cancer, which could help explore potential therapeutic decisions and regulatory mechanisms of CAF-specific lncRNAs.

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Knockdown of lncRNA LINC01234 Suppresses the Tumorigenesis of Liver Cancer via Sponging miR-513a-5p

Cited by 20 publications

References 46 publications

The lncRNA Signatures of Genome Instability to Predict Survival in Patients with Renal Cancer

The lncRNA Signatures of Genome Instability to Predict Survival in Patients with Renal Cancer

LINC01234 Accelerates the Progression of Breast Cancer via the miR-525-5p/Cold Shock Domain-Containing E1 Axis

Cancer-associated fibroblasts-derived lncRNA signature as a putative biomarker in breast cancer

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