2017
DOI: 10.1007/s00432-017-2543-y
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Abstract: Our finding suggested that knockdown of ANRIL suppressed cell proliferation, metastasis and invasion via regulating miR-122-5p expression in HCC, illustrating the underlying mechanism of the oncogenic role of ANRIL in HCC.

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Cited by 100 publications
(80 citation statements)
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“…11 Overexpression of the lncRNA SNHG16 can inhibit HCC proliferation by sponging hsa-miR-93. 13 It has been evidenced that LINC00346 is upregulated in several cancers and can play oncogenic roles. 13 It has been evidenced that LINC00346 is upregulated in several cancers and can play oncogenic roles.…”
Section: Introductionmentioning
confidence: 99%
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“…11 Overexpression of the lncRNA SNHG16 can inhibit HCC proliferation by sponging hsa-miR-93. 13 It has been evidenced that LINC00346 is upregulated in several cancers and can play oncogenic roles. 13 It has been evidenced that LINC00346 is upregulated in several cancers and can play oncogenic roles.…”
Section: Introductionmentioning
confidence: 99%
“…12 In addition, knockdown of ANRIL is able to repress HCC progression through modulating miR-122-5p. 13 It has been evidenced that LINC00346 is upregulated in several cancers and can play oncogenic roles. 14,15 For instance, LINC00346 is increased in pancreatic cancer and serves as a prognostic marker.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, lncRNA ANRIL could promote the progression of papillary thyroid cancer and osteosarcoma . Notably, lncRNA ANRIL is found to be upregulated in HCC and knockdown of ANRIL suppress HCC cell proliferation, migration, and invasion ability . However, its roles in regulating the mitochondrial function of HCC cells have never been elucidated.…”
Section: Introductionmentioning
confidence: 99%
“…In gastric cancer, the impact of ANRIL on proliferation and apoptosis was mediated by the epigenetic silencing of miR-99a and miR-449a, two miRNAs known to target mTOR and CDK6/E2F1 pathways 42 . In ovarian 43 and bladder 44 In HCC, sponging of liver enriched miR-122-5p by ANRIL induces cell proliferation, metastasis and invasion 47 . Interestingly, ANRIL was reported to contribute to paclitaxel resistance in lung cancer, partly through poly(ADP-ribose) polymerase (PARP) and BCL2 modulating mitochondrial pathway 48 .…”
mentioning
confidence: 99%