volume 7, issue 8, P553-567 2015
DOI: 10.18632/aging.100791
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Franziska Schwarz, Zehra Karadeniz, Antje Fischer-Rosinsky, Diana M Willmes, Joachim Spranger, Andreas L Birkenfeld

Abstract: Reducing the expression of the Indy (Acronym for ‘I'm Not Dead, Yet’) gene in lower organisms promotes longevity and leads to a phenotype that resembles various aspects of caloric restriction. In C. elegans, the available data on life span extension is controversial. Therefore, the aim of this study was to determine the role of the C. elegans INDY homolog CeNAC2 in life span regulation and to delineate possible molecular mechanisms. siRNA against Indy/CeNAC2 was used to reduce expression of Indy/CeNAC2. Mean l…

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