Knee intra-articular administration of stromal vascular fraction obtained from adipose tissue: A systematic review

Aletto, Cristian; Oliva, Francesco; Maffulli, Nicola

doi:10.1016/j.jcot.2022.101773

Cited by 10 publications

(14 citation statements)

References 38 publications

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“…A recent work showed that patients treated at earlier‐degeneration stages reported statistically significant improvements in VAS, WOMAC and walking distance [22]. Similarly, several recent systematic reviews and meta‐analysis reported favorably on the use of MSCs [1]. Wiggers et al found a positive effect of autologous MSC therapy compared with control treatments on patient‐reported outcome measures, and disease severity [29].…”

Section: Discussionmentioning

confidence: 99%

Age and synovitis affect the results of the treatment of knee osteoarthritis with Microfragmented Autologous Fat Tissue

Ferracini

Alessio-Mazzola

Sonzogni

et al. 2022

Knee Surg Sports Traumatol Arthrosc

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Purpose This study aims to assess the effectiveness of Microfragmented Autologous Fat Tissue (MFAT) treatment for knee osteoarthritis and to investigate whether patients’ pre-treatment clinical condition, such as synovitis, correlates with clinical outcomes, to identify potential predicting factors for the success or failure of the treatment. Methods In this prospective Cohort Study Level II multicentric trial, consecutive patients with a diagnosis of early/mild osteoarthritis and failure of previous conservative measures were enrolled to undergo diagnostic arthroscopy and a single MFAT injection. Patients were assessed with repeated scoring systems at baseline, 6 months, and 12 months after surgery. The demographic features, the arthroscopic findings, the immunophenotype of injected tissue and the histologic examination of synovia of failed patients were analyzed. Results Data from 91 patients showed a significant improvement in Lysholm, WOMAC scores at 1-year follow-up (p < 0.001). A significant decrease in VAS score was observed, while a significant improvement of measured flexion angle was registered at 1 year (p < 0.001). No major complications were reported. Age and synovitis were identified as significant factors influencing the clinical outcome (p < 0.05). Body mass index, previous or concomitant procedures, and specific cartilage defects had no influence. The mean number of injected adipose tissue-derived mesenchymal stem cells seem not to correlate with the clinical outcome. Conclusion MFAT is effective in reducing pain when used with a single dose injection in early/mild OA of the knee, without major complications. Age over 60 and synovitis may be predictive for persistent pain at one year and should be considered before indications.

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Section: Discussionmentioning

confidence: 99%

Age and synovitis affect the results of the treatment of knee osteoarthritis with Microfragmented Autologous Fat Tissue

Ferracini

Alessio-Mazzola

Sonzogni

et al. 2022

Knee Surg Sports Traumatol Arthrosc

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“…As much as 90 mL of lipoaspirate is typically obtained through the liposuction process. Recent clinical studies have revealed that SVF provides functional improvements and pain relief for 6 to 24 months compared with a placebo 28 . The consensus is that the previously mentioned biological agents have a favorable safety profile with a low risk of adverse reactions.…”

Section: Cell Therapymentioning

confidence: 99%

Orthobiologics and the Treatment of Knee Osteoarthritis

Bishop,

Rizzolo

2024

JBJS Journal of Orthopaedics for Physician Assistants

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“…The SVF has proven its effectiveness in the treatment of various diseases. A number of studies have confirmed its beneficial effect on osteoarthritis, both when used independently and in combination with other components, such as PRP ( 17 - 24 ). The SVF is actively used in aesthetic medicine: in rejuvenation procedures ( 25 ), as well as for the clinical treatment of various forms of alopecia ( 26 , 27 ) and acne ( 28 ).…”

Section: Introductionmentioning

confidence: 95%

Effectiveness and Safety of Transplantation of the Stromal Vascular Fraction of Autologous Adipose Tissue for Wound Healing in the Donor Site in Patients with Third-Degree Skin Burns: A Randomized Trial

Ryabkov,

Egorikhina,

Koloshein

et al. 2023

MJIRI

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Background The quality of the wound healing at the donor site significantly determines the overall condition of the burn patient, the extent of wound fluid and protein losses, the severity of any systemic in-flammatory reaction, and the intensity of the pain syndrome. It is known that the stromal vas-cular fraction (SVF) has a beneficial effect on the healing of wound defects. This study is aimed at assessing the safety and effectiveness of the application of the SVF of autologous adipose tis-sue to stimulate wound healing of the donor site in patients with burns. Methods This placebo-controlled clinical study included 38 patients with third-degree thermal skin burns. The patients underwent liposuction, enzymatic isolation of the SVF, and intradermal injection of the preparation into the wounds in the donor site, followed by tewametry, cutome-try, thermography and biopsy after 12 days. Quantitative indicators were compared using the Mann-Whitney test for unrelated groups and the Wilcoxon test for related groups. Spearman's rank correlation coefficient (RS) was used to assess the correlation Results Epithelization of the wounds in all patients was seen over an average area of 88 (84;92) %, there being no significant differences between the actual and the control wound sites for this parameter. Transdermal water loss in the test wound sites was 2 times lower than in the control sites ( P = 0.001). The wound donor sites regained their temperature distribution faster than the control sites ( P = 0.042). Histological preparations of the skin of the wound sites revealed that their epidermal layer was 19% thicker compared to the controls ( P = 0.043). It should be noted that five adverse events related to manipulations in the postoperative period were registered. Conclusion Transplantation of SVF autologous adipose tissue into the wound area in most clinical cases proceeded without complications. The area of epithelialization of wound areas af-ter the introduction of SVF did not change, although a significant decrease in transdermal water loss was observed in the wound areas with an improvement in their thermoregulation and an increase in the thickness of the epidermis.

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Knee intra-articular administration of stromal vascular fraction obtained from adipose tissue: A systematic review

Cited by 10 publications

References 38 publications

Age and synovitis affect the results of the treatment of knee osteoarthritis with Microfragmented Autologous Fat Tissue

Age and synovitis affect the results of the treatment of knee osteoarthritis with Microfragmented Autologous Fat Tissue

Orthobiologics and the Treatment of Knee Osteoarthritis

Effectiveness and Safety of Transplantation of the Stromal Vascular Fraction of Autologous Adipose Tissue for Wound Healing in the Donor Site in Patients with Third-Degree Skin Burns: A Randomized Trial

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