2019
DOI: 10.1152/ajprenal.00625.2017
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Abstract: Sepsis-induced organ failure is characterized by a massive inflammatory response and oxidative stress. Acute kidney injury (AKI) occurs in approximately half of patients in septic shock, and the mortality associated with sepsis-induced AKI is unacceptably high. Klotho is a protein expressed by renal cells and has anti-senescence properties. Klotho has also been shown to protect the kidneys in ischemia-reperfusion injury and to have antioxidant properties. To analyze the role of Klotho in sepsis-related organ d… Show more

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Cited by 23 publications
(19 citation statements)
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“…Although the present study suggests the disruption in the function and/or differentiation of immune cells in klotho KO mice, it remains unclear how klotho KO mice died from infection with A. baumannii. A previous study reported that klotho deficiency aggravates sepsis-related multiple organ dysfunction (31). Thus, one possible reason for eventually death might be incomplete bacteria clearance and worsen multiple organ dysfunction.…”
Section: Discussionmentioning
confidence: 96%
See 1 more Smart Citation
“…Although the present study suggests the disruption in the function and/or differentiation of immune cells in klotho KO mice, it remains unclear how klotho KO mice died from infection with A. baumannii. A previous study reported that klotho deficiency aggravates sepsis-related multiple organ dysfunction (31). Thus, one possible reason for eventually death might be incomplete bacteria clearance and worsen multiple organ dysfunction.…”
Section: Discussionmentioning
confidence: 96%
“…A klotho-septic mouse model that displayed hypercytokinemia with impaired bacterial clearance and increased apoptosis of lymphocytes may be related to poor survival in klotho KO mice treated with cecal ligation and puncture (30). Additionally, a previous study reported that klotho deficiency aggravates sepsis-related multiple organ dysfunction (31). Thus, klotho KO mice are expected to be useful as an animal model for the clarification of pathogenesis of bacterial infections in aged hosts.…”
Section: Introductionmentioning
confidence: 99%
“…However, male CLP mice did not generally exhibit a significant decrease in Klotho protein abundance. Other studies using male mice showed a reduction of Klotho expression after inflammatory stimuli [101,[106][107][108]. Therefore, we do not have a good explanation for the sex difference in Klotho expression in CLP mice.…”
Section: Plos Onementioning
confidence: 63%
“…Sepsis-induced multiple organs failure is characterized by an imbalance between the pro-and anti-inflammatory systems (21). AKI occurs in more than 50% of patients with septic shock, and its associated mortality is unacceptably high (24). Unfortunately, effective preventive treatments are still lacking (20).…”
Section: Discussionmentioning
confidence: 99%