Kinetics and mechanism of oxidation of n-butylamine and 1,3-propanediamine by potassium ferrate

Abstract

KEYWORDSThe kinetics of oxidation of n-butylamine and 1,3-propanediamine by home-made potassium ferrate(VI) at different conditions has been studied spectrophotometrically in the temperature range of 283.2-298.2 K. The results show first order dependence on potassium ferrate (VI) and on each reductant. The observed rate constant (kobs) decreases with the increase of [OH -], and the reaction rate has a negative fraction order with respect to [OH -]. A plausible mechanism is proposed and the rate equations derived from the mechanism was shown to fit all the experimental results. The rate constants of the rate-determining step and the thermodynamic activation parameters are calculated.

Natural Compound‐Rhein and PROTACs Unleash Potent VEGFR‐2 Degraders

“…Similarly, PROTAC‐2 and PROTAC‐5, designed and synthesized by Shan et al. achieved VEGFR‐2 degradation in EA.HY926 cells [23,24] . These findings underscore the feasibility of applying PROTAC technology to the targeted degradation of VEGFR‐2.…”

Natural Compound‐Rhein and PROTACs Unleash Potent VEGFR‐2 Degraders

“…Similarly, PROTAC‐2 and PROTAC‐5, designed and synthesized by Shan et al. achieved VEGFR‐2 degradation in EA.HY926 cells [23,24] . These findings underscore the feasibility of applying PROTAC technology to the targeted degradation of VEGFR‐2.…”

Oxidation and Reduction

“…A similar synthesis of 1,1 -binaphthyl-2,2 -diamines from 2-naphthylamines was also described. 126 The alkaline Fe(VI) oxidations of 2-methoxy-and 2-ethoxy-ethanol 127 and isobutylamine and 1,4-butanediamine 128 were first order in Fe(VI) and substrates. In the case of alcohol k obs decreased with increasing [OH − ], there being a negative fractionalorder dependence in [OH − ] in the case of amines.…”

“…274 Cinnamyl cinnamate derivatives were obtained in good to excellent yields by esterification of α,β-unsaturated aldehydes, including aromatic aldehydes, with cinnamyl bromides in the presence of DBU, K 2 CO 3 , THF, and t-BuOH using either atmospheric O 2 or MnO 2 as the oxidant and N-heterocyclic carbene (NHC) as the catalyst. The use of 18 275 The synthesis of isoindolinones (128) from N-tosylbenzamides (129) and t-butyl acrylate was achieved in high yields using O 2 as oxidant and Pd(OAc) 2 as catalyst in the presence of 4,7-diphenyl-1,10-phenanthroline and toluene. Aliphatic alkenes with electron-rich and electron-deficient alkenes or conjugated alkenes could also be used.…”

Natural Compound‐Rhein and PROTACs Unleash Potent VEGFR‐2 Degraders

“…Similarly, PROTAC‐2 and PROTAC‐5, designed and synthesized by Shan et al. achieved VEGFR‐2 degradation in EA.HY926 cells [23,24] . These findings underscore the feasibility of applying PROTAC technology to the targeted degradation of VEGFR‐2.…”

Oxidation and Reduction

“…A similar synthesis of 1,1 -binaphthyl-2,2 -diamines from 2-naphthylamines was also described. 126 The alkaline Fe(VI) oxidations of 2-methoxy-and 2-ethoxy-ethanol 127 and isobutylamine and 1,4-butanediamine 128 were first order in Fe(VI) and substrates. In the case of alcohol k obs decreased with increasing [OH − ], there being a negative fractionalorder dependence in [OH − ] in the case of amines.…”

“…274 Cinnamyl cinnamate derivatives were obtained in good to excellent yields by esterification of α,β-unsaturated aldehydes, including aromatic aldehydes, with cinnamyl bromides in the presence of DBU, K 2 CO 3 , THF, and t-BuOH using either atmospheric O 2 or MnO 2 as the oxidant and N-heterocyclic carbene (NHC) as the catalyst. The use of 18 275 The synthesis of isoindolinones (128) from N-tosylbenzamides (129) and t-butyl acrylate was achieved in high yields using O 2 as oxidant and Pd(OAc) 2 as catalyst in the presence of 4,7-diphenyl-1,10-phenanthroline and toluene. Aliphatic alkenes with electron-rich and electron-deficient alkenes or conjugated alkenes could also be used.…”

Natural Compound‐Rhein and PROTACs Unleash Potent VEGFR‐2 Degraders

“…Similarly, PROTAC‐2 and PROTAC‐5, designed and synthesized by Shan et al. achieved VEGFR‐2 degradation in EA.HY926 cells [23,24] . These findings underscore the feasibility of applying PROTAC technology to the targeted degradation of VEGFR‐2.…”

Oxidation and Reduction

“…A similar synthesis of 1,1 -binaphthyl-2,2 -diamines from 2-naphthylamines was also described. 126 The alkaline Fe(VI) oxidations of 2-methoxy-and 2-ethoxy-ethanol 127 and isobutylamine and 1,4-butanediamine 128 were first order in Fe(VI) and substrates. In the case of alcohol k obs decreased with increasing [OH − ], there being a negative fractionalorder dependence in [OH − ] in the case of amines.…”

“…274 Cinnamyl cinnamate derivatives were obtained in good to excellent yields by esterification of α,β-unsaturated aldehydes, including aromatic aldehydes, with cinnamyl bromides in the presence of DBU, K 2 CO 3 , THF, and t-BuOH using either atmospheric O 2 or MnO 2 as the oxidant and N-heterocyclic carbene (NHC) as the catalyst. The use of 18 275 The synthesis of isoindolinones (128) from N-tosylbenzamides (129) and t-butyl acrylate was achieved in high yields using O 2 as oxidant and Pd(OAc) 2 as catalyst in the presence of 4,7-diphenyl-1,10-phenanthroline and toluene. Aliphatic alkenes with electron-rich and electron-deficient alkenes or conjugated alkenes could also be used.…”