J Biol Inorg Chem volume 19, issue 3, P349-357 2013 DOI: 10.1007/s00775-013-1070-9 View full text
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Maram T. Basha, Carlos Rodríguez, Des R. Richardson, Manuel Martínez, Paul V. Bernhardt

Abstract: The oxidation of oxyhemoglobin to methemoglobin has been found to be facilitated by low molecular weight iron(III) thiosemicarbazone complexes. This deleterious reaction, which produces hemoglobin protein units unable to bind dioxygen and occurs during the administration of iron chelators such as the well-known 3-aminopyridine-2-pyridinecarbaldehyde thiosemicarbazone (3-AP; Triapine), has been observed in the reaction with Fe(III) complexes of some members of the 3-AP structurally-related thiosemicarbazone lig…

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