1990
DOI: 10.1590/s0036-46651990000300004
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Kinectics of the pulmonary phase of Schistosoma mansoni in mice treated with dexamethasone

Abstract: In the experimental schistosomiasis mansoni glucocorticoids cause a reduction in the worm burden when administered in the week of infection or, the longest, at the next week. In order to determinate the probable(s) site(s) of reduction of the worm burden, mice were infected with cercariae of LE strain of S. mansoni and dexamethasone was administered daily (50 mg/kg, subcutaneously) starting 1 hour before infection until the eighth day. Mice were sacrificed daily starting on the third day after infection until … Show more

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Cited by 8 publications
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“…We have reported that the pharmacological effects of DDB include inhibition of NF-KB activation and of TNFβ (Salama et al 2004). Previous studies of the effects of corticoids on murine schistosomiasis showed variable effects that depended on the type of corticoid administered, the dose and the schedule of treatment (Harrison & Doenhoff 1983, Morrison et al 1986, Hermeto et al 1990). It was proposed that the decrease in worm burden that occurred following corticoid treatment was due to impairment of the initial phase of parasite penetration into host tissues (Hermeto et al 1994).…”
mentioning
confidence: 99%
“…We have reported that the pharmacological effects of DDB include inhibition of NF-KB activation and of TNFβ (Salama et al 2004). Previous studies of the effects of corticoids on murine schistosomiasis showed variable effects that depended on the type of corticoid administered, the dose and the schedule of treatment (Harrison & Doenhoff 1983, Morrison et al 1986, Hermeto et al 1990). It was proposed that the decrease in worm burden that occurred following corticoid treatment was due to impairment of the initial phase of parasite penetration into host tissues (Hermeto et al 1994).…”
mentioning
confidence: 99%