Journal of Cell Biology volume 217, issue 4, P1431-1451 2018 DOI: 10.1083/jcb.201612177 View full text
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Ling Guo, Ting Cai, Keng Chen, Rong Wang, Jiaxin Wang, Chunhong Cui, Jifan Yuan, Kuo Zhang, Zhongzhen Liu, Yi Deng, Guozhi Xiao, Chuanyue Wu

Abstract: Mesenchymal stem cell (MSC) fate decision is strongly influenced by cell microenvironment. Guo et al. identify kindlin-2 as a key determinant of MSC lineage commitment and delineate a novel signaling pathway consisting of kindlin-2, RhoA, MLCK, AIP4, and YAP1/TAZ that senses mechanical cues of the cell microenvironment and controls MSC differentiation.