Kindler′s syndrome: A tale of two siblings

Abstract

Kindler's syndrome (KS) is a rare inherited skin disease characterized by acral blistering, photosensitivity, progressive poikiloderma, and cutaneous atrophy along with different types of mucosal involvement. We hereby report KS in two siblings. The case is being reported for its rarity and for emphasizing the importance of considering this condition in the differential diagnosis of disorders that may cause blistering, cutaneous atrophy, and/or poikilodermatous skin changes. Besides, the presentation of the disease in two of the members of the same family makes the case even more interesting.

Models of optimization of combination of production of agrarian products and harvesting of wild food resources

“…where t is parameter. Model (7), (8), (11) -(13), (14), (15) involves the use of one parameter. At the same time, it is possible to apply deterministic multi-parameter linear programming problems to describe real situations.…”

“…Although climate variability towards warming is not so significant in the region, especially in the north, nevertheless, it is necessary to study possible scenarios of spatiotemporal changes in species and yields of wild-growing products, as the authors of the article emphasize [14].…”

Kindler syndrome: a rare case report from Greece

“…Mucous membrane involvement is common and may lead to severe disability, due to stenoses of the mucosal cavities. Other features include pseudosyndactyly Ainhum, nail dystrophy, palmoplantar keratoderma, ectropion, keratoconjuctivitis and conjuctival scarring [5].…”

“…The histopathological analysis of atrophic skin lesions demonstrates non-specific features, whereas transmission electron microscopy of KS skin reveals major disorganization of the basement membrane, single or multiple cleavage planes at the level of the cutaneous basement membrane and reduplicaton of the lamina densa [3, 5].…”

“…KS must be differentiated from epidermolysis bullosa, Rothmund–Thompson syndrome and other congenital poikilodermatous and photosensitive conditions [3, 5]. Rothmund–Thompson syndrome is characterized by poikiloderma and photosensitivity which are also associated with hypogonadism, short stature, cataract and sparse hair [4–6].…”