Kin17 high expression as a potential biomarker for high‐grade cervical intraepithelial neoplasia

Marques, Lais de S.; Violin, Vanessa G. A.; Meireles, Lyvia E. de F.; Souza, Maria Vítoria Felipe de; Mari, Natália L.; Damke, Gabrielle Marconi Zago Ferreira; Damke, Edílson; Pereira, Monalisa Wolski; Shinobu-Mesquita, Cristiane Suemi; Silva, Vânia R. S. da; Consolaro, Márcia Edilaine Lopes

doi:10.1002/ijgo.14437

Cited by 2 publications

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“…Of note, a recent study found that the expression level of KIN17 was positively associated with the severity of cervical lesions, indicating that KIN17 is a novel protein biomarker for high-grade CIN (62). High-grade CIN is considered to be the precursor of cervical carcinoma, which further suggests that KIN17 may be used as a predictive biomarker for cervical cancer.…”

Section: Roles Of Kin17 In Cancer Cellsmentioning

confidence: 99%

Roles and regulatory mechanisms of KIN17 in cancers (Review)

Huang

Dai

et al. 2023

Oncol Lett

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KIN17, which is known as a DNA and RNA binding protein, is highly expressed in numerous types of human cancers and was discovered to participate in several vital cell behaviors, including DNA replication, damage repair, regulation of cell cycle and RNA processing. Furthermore, KIN17 is associated with cancer cell proliferation, migration, invasion and cell cycle regulation by regulating pathways including the p38 MAPK, NF-κB-Snail and TGF-β/Smad2 signaling pathways. In addition, knockdown of KIN17 was found to enhance the sensitivity of tumor cells to chemotherapeutic agents. Immunohistochemical analysis revealed that there were significant differences in the expression of KIN17 between cancer tissues and adjacent tissues. Both the Kaplan-Meier survival analysis and multivariate Cox regression analysis indicated that KIN17 is aberrantly high expressed in various tumor tissues and is also associated with poor prognosis in patients with various tumor types. Taken together, KIN17 has key roles in tumorigenesis and cancer development. Investigating the relationship between KIN17 and neoplasms will provide a vital theoretical basis for KIN17 to serve as a diagnostic and prognostic biomarker for cancer patients and as a potential target for cancer therapy.

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Section: Roles Of Kin17 In Cancer Cellsmentioning

confidence: 99%