Kikuchi-Fujimoto Disease: Report of a Case with Progression to Lupus Nephritis

Hurtado-Díaz, Jorge; Espinoza-Sánchez, María Lucero; Rojas-Milán, Eduardo; Cimé-Aké, Erik; Macias, María de Los Ángeles; Romero-Ibarra, Lizeth; Vera‐Lastra, Olga

doi:10.12659/ajcr.927351

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…Many studies suggest a correlation between KFD and SLE, with comorbidity up to 13%–25%. Nevertheless, the aetiological link between these remains unproven 11 12. In the case of our patient, as for most patients with KFD, no clear underlying cause was identified.…”

Section: Discussionmentioning

confidence: 67%

Abdominal Kikuchi-Fujimoto lymphadenopathy: an uncommon presentation of a rare disease

et al. 2022

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A 34-year-old man presented to our hospital with a 5-day history of progressive abdominal pain and fever. A CT scan identified extensive mesenteric lymphadenopathy. Initial diagnostic tests were inconclusive. Abdominal lymph node biopsy showed histiocytic necrotising lymphadenitis, compatible with Kikuchi-Fujimoto disease (KFD). This benign and self-limiting disease generally resolves following supportive treatment. In this case, remission occurred within 3 weeks of initial presentation. KFD is a very uncommon cause of lymphadenopathy, and selective mesenteric involvement is rare. Definitive diagnosis often requires lymph node biopsy. It is important to exclude more common and serious differential diagnoses associated with mesenteric lymphadenopathy, while maintaining a minimally invasive diagnostic approach, before progressing to nodal biopsy.

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Section: Discussionmentioning

confidence: 67%

Abdominal Kikuchi-Fujimoto lymphadenopathy: an uncommon presentation of a rare disease

et al. 2022

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“…Due to the possible immune nature of KFD, it is no surprise that the association of KFD with rheumatological autoimmune diseases has been well-documented in the literature, with the KFD diagnosis established before, during, and after SLE and SS [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. Although the first case of KFD is traced to 1972 in Japan where it was described almost simultaneously by Kikuchi and Fujimoto, more and more cases are now being diagnosed in the Western world as well [26,27].…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto Disease With Systemic Lupus Erythematosus and Systemic Sclerosis Overlap: A Unique Clinical Presentation

Rana,

Fatima,

Rana

et al. 2023

Cureus

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Kikuchi-Fujimoto Disease (KFD), or histiocytic necrotizing lymphadenitis (HNL), is a rare self-limiting disorder presenting with fever and swollen lymph nodes. It is characterized by the focal proliferation of reticular cells, the presence of nuclear debris, and histiocytes. In advanced cases, it can present with hepato-splenomegaly and generalized lymphadenopathy. Historically, it has been associated with viral infections, as it frequently was found to be associated with upper respiratory symptoms. Alternative explanations include the immune response of T-cells leading to alteration in CD8-positive T-cell-mediated cell apoptosis. It is also speculated that KFD can be associated with rheumatological autoimmune diseases. We present a case of a 21-year-old African American female with a known diagnosis of systemic lupus erythematosus (SLE)-systemic sclerosis (SS) overlap presented with febrile lymphadenopathy and was diagnosed to have HNL on histological exam of lymph node biopsy.

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“…Although the exact pathophysiology of KFD is not fully understood, an autoimmune and infectious workup should be considered in patients with suspected KFD. KFD typically resolves spontaneously within months, but patients should be monitored after resolution of symptoms as there are reports of recurrence of KFD as well as coexistence with and progression to SLE [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto Disease: A Differential for When It is Not Systemic Lupus Erythematosus

Kazmi

Greear

Lavallee

et al. 2022

Case Reports in Rheumatology

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Kikuchi-Fujimoto disease (KFD) is a rare and benign disease process that is characterized by fever and lymphadenopathy that was first described in young Japanese women in the early 1970s. Knowledge of KFD is important as it can often mimic other causes of lymphadenopathy including systemic lupus erythematosus (SLE) or malignancies, and this can lead to invasive diagnostic testing and even treatments that can be avoided. The etiology and exact mechanism by which KFD develops is not fully understood at this time, but is thought to be an immune response of T cells and histiocytes to viral or bacterial infections. We present a 35-year-old African-American woman who was referred to the rheumatology clinic by our colleagues in the breast clinic with new onset right axillary lymphadenopathy and abnormal serologic testing with the suspicion of SLE after a malignancy had been ruled out.

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Kikuchi-Fujimoto Disease: Report of a Case with Progression to Lupus Nephritis

Cited by 5 publications

References 18 publications

Abdominal Kikuchi-Fujimoto lymphadenopathy: an uncommon presentation of a rare disease

Abdominal Kikuchi-Fujimoto lymphadenopathy: an uncommon presentation of a rare disease

Kikuchi-Fujimoto Disease With Systemic Lupus Erythematosus and Systemic Sclerosis Overlap: A Unique Clinical Presentation

Kikuchi-Fujimoto Disease: A Differential for When It is Not Systemic Lupus Erythematosus

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