KH 1060 for the Treatment of Lichen Planus: A Multicenter, Randomized, Double-blind, Vehicle-Controlled Study

Bouloc, Anne; Revuz, J; Bagot, Martine; Wechsler, Janine; Natta, Patrick

doi:10.1001/archderm.136.10.1272

Cited by 7 publications

(2 citation statements)

References 5 publications

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“…Two RCTs and one open-label trial have been conducted on the use of topical vitamin D analogues in the treatment of lichen planus in a total of 139 patients. [136][137][138] A multicenter, double-blind RCT by Bouloc and colleagues concluded that there was no difference in redness, pruritus, and lesional thickness between KH 1060 (a potent topical vitamin D analogue) and vehicle-treated groups after 8 weeks (n 5 92). 137 However, 11 of 49 (22.4%) and 7 of 43 (16.3%) patients were lost to follow-up in the KH 1060-and vehicle-treated groups, respectively, and no explanation was provided.…”

Section: Lichen Planusmentioning

confidence: 99%

“…[136][137][138] A multicenter, double-blind RCT by Bouloc and colleagues concluded that there was no difference in redness, pruritus, and lesional thickness between KH 1060 (a potent topical vitamin D analogue) and vehicle-treated groups after 8 weeks (n 5 92). 137 However, 11 of 49 (22.4%) and 7 of 43 (16.3%) patients were lost to follow-up in the KH 1060-and vehicle-treated groups, respectively, and no explanation was provided. A subsidiary RCT analyzing histologic changes in a subset of 10 patients from the same multicenter study demonstrated significant inhibition of epidermal proliferation after 8 weeks of KH 1060 treatment.…”

Section: Lichen Planusmentioning

confidence: 99%

See 1 more Smart Citation

Off-Label Uses of Topical Vitamin D in Dermatology: A Systematic Review

Wat

Dytoc

2014

J Cutan Med Surg

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Section: Lichen Planusmentioning

confidence: 99%

Section: Lichen Planusmentioning

confidence: 99%

Off-Label Uses of Topical Vitamin D in Dermatology: A Systematic Review

Wat

Dytoc

2014

J Cutan Med Surg

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Interventions for treating oral lichen planus

Thongprasom

Carrozzo

Furness

et al. 2011

Cochrane Database of Systematic Reviews

136

131

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Interventions for treating oral lichen planus: corticosteroid therapies

Lodi

Manfredi

Mercadante

et al. 2020

Cochrane Database of Systematic Reviews

100

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Background Oral lichen planus (OLP) is a relatively common chronic T cell-mediated disease, which can cause significant pain, particularly in its erosive or ulcerative forms. As pain is the indication for treatment of OLP, pain resolution is the primary outcome for this review. This review is an update of a version last published in 2011, but focuses on the evidence for corticosteroid treatment only. A second review considering non-corticosteroid treatments is in progress. Objectives To assess the e ects and safety of corticosteroids, in any formulation, for treating people with symptoms of oral lichen planus. Search methods Cochrane Oral Health's Information Specialist searched the following databases to 25 February 2019: Cochrane Oral Health's Trials Register, CENTRAL (2019, Issue 1), MEDLINE Ovid, and Embase Ovid. ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform were searched for ongoing trials. There were no restrictions on language or date of publication. Selection criteria We considered randomised controlled clinical trials (RCTs) of any local or systemic corticosteroid treatment compared with a placebo, a calcineurin inhibitor, another corticosteroid, any other local or systemic (or both) drug, or the same corticosteroid plus an adjunctive treatment. Data collection and analysis Three review authors independently scanned the titles and abstracts of all reports identified, and assessed risk of bias using the Cochrane tool and extracted data from included studies. For dichotomous outcomes, we expressed the estimates of e ects of an intervention as risk ratios (RR), with 95% confidence intervals (CI). For continuous outcomes, we used mean di erences (MD) and 95% CI. The statistical unit of analysis was the participant. We conducted meta-analyses only with studies of similar comparisons reporting the same outcome measures. We assessed the overall certainty of the evidence using GRADE. Main results We included 35 studies (1474 participants) in this review. We assessed seven studies at low risk of bias overall, 11 at unclear and the remaining 17 studies at high risk of bias. We present results for our main outcomes, pain and clinical resolution measured at the end of Interventions for treating oral lichen planus: corticosteroid therapies (Review)

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KH 1060 for the Treatment of Lichen Planus: A Multicenter, Randomized, Double-blind, Vehicle-Controlled Study

Cited by 7 publications

References 5 publications

Off-Label Uses of Topical Vitamin D in Dermatology: A Systematic Review

Off-Label Uses of Topical Vitamin D in Dermatology: A Systematic Review

Interventions for treating oral lichen planus

Interventions for treating oral lichen planus: corticosteroid therapies

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