Key players in the immune response to biomaterial scaffolds for regenerative medicine

Chung, Liam; Maestas, David R.; Housseau, Franck; Elisseeff, Jennifer H.

doi:10.1016/j.addr.2017.07.006

Cited by 276 publications

(199 citation statements)

References 126 publications

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“…The advantages of this kind of graft are varied such as decreasing infection risk, which might be a possibility with the use of allografts and xenografts (Sheikh et al, ) Tissue Researchers have forced new treatment approaches for bone repair and regeneration to address limitations associated with current therapies. Synthetic biomaterial can be specifically decreasing and modulating the immune response for enhancing tissue repair and regeneration (Chung, Housseau, & Elisseeff, ).…”

Section: Nanofibrous Fabrication Methodsmentioning

confidence: 99%

Bone tissue engineering: Adult stem cells in combination with electrospun nanofibrous scaffolds

Moradi

Golchin

Hajishafieeha

et al. 2018

Journal Cellular Physiology

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Since bone tissue lesions caused by several reasons and has global outbreak without any attentions to the modernity level of the countries. In the other hands treatment of patients with this problem faced to the several limitations, in this because the future of the bone lesions treatments is related to the future of the bone tissue engineering. This review tries to cover the most suitable stem cells and materials from either natural or synthetic sources for bone tissue engineering. These understanding points would help researchers to further uncover the application of different adult stem cell sources in electrospinning scaffolds, promotion of nanofibrous composite construct design and adult stem cell type selection to enhance cell function and bone tissue engineering, and link laboratory investigations to clinical applications.

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Section: Nanofibrous Fabrication Methodsmentioning

confidence: 99%

Bone tissue engineering: Adult stem cells in combination with electrospun nanofibrous scaffolds

Moradi

Golchin

Hajishafieeha

et al. 2018

Journal Cellular Physiology

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show abstract

“…Several material platforms involve co-delivering replacement tissue or cells with immunomodulatory factors before or during transplantation, or using materials for immune isolation [92,93]. Recently, scaffolds have been used to target immune signals and drugs [94– 96].…”

Section: Biomaterials Improve Targeting Selectivity and Potency Ofmentioning

confidence: 99%

Improving Vaccine and Immunotherapy Design Using Biomaterials

Bookstaver

Tsai

Bromberg

et al. 2018

Trends in Immunology

157

113

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“…Relatively less studied in the context of regeneration is the adaptive immune response but recent work has begun to elucidate the role of T cells in the immune microenvironment and, similar to macrophages, Th-2 cells have been shown to accelerate bone healing [184] and regeneration of injured muscle [185, 186]. There is still much to be learned about the mechanisms of matrix-based materials in generating a therapeutic immune response, but it’s clear that a regulated scaffold immune microenvironment is a critical component of the regenerative niche [106, 187, 188]. …”

Section: Matrix-based Materials For Modulating Tissue Repairmentioning

confidence: 99%

Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair

Keane

Horejs

Stevens

2018

Advanced Drug Delivery Reviews

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All vertebrates possess mechanisms to restore damaged tissues with outcomes ranging from regeneration to scarring. Unfortunately, the mammalian response to tissue injury most often culminates in scar formation. Accounting for nearly 45% of deaths in the developed world, fibrosis is a process that stands diametrically opposed to functional tissue regeneration. Strategies to improve wound healing outcomes therefore require methods to limit fibrosis. Wound healing is guided by precise spatiotemporal deposition and remodelling of the extracellular matrix (ECM). The ECM, comprising the non-cellular component of tissues, is a signalling depot that is differentially regulated in scarring and regenerative healing. This Review focuses on the importance of the native matrix components during mammalian wound healing alongside a comparison to scar-free healing and then presents an overview of matrix-based strategies that attempt to exploit the role of the ECM to improve wound healing outcomes.

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Key players in the immune response to biomaterial scaffolds for regenerative medicine

Cited by 276 publications

References 126 publications

Bone tissue engineering: Adult stem cells in combination with electrospun nanofibrous scaffolds

Bone tissue engineering: Adult stem cells in combination with electrospun nanofibrous scaffolds

Improving Vaccine and Immunotherapy Design Using Biomaterials

Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair

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