Ketorolac Use for Postoperative Pain Management Following Lumbar Decompression Surgery

Abstract

There were no significant differences in available patient demographics, intraoperative blood loss, or postoperative Hemovac drain output between study groups. Morphine equivalent requirements were significantly less at all predetermined time points in addition to the overall hospital morphine requirement in patients randomized to receive Ketorolac. Visual Analog Pain Scores were significantly lower in patients randomized to receive Ketorolac immediately postoperative in addition to 4, 12, and 16 hours postoperative. There were no identifiable postoperative complications associated with the use of Ketorolac. CONCLUSION.: Intravenous Ketorolac seems to be a safe and effective analgesic agent following multilevel lumbar decompressive laminectomy. Patients can expect lower morphine requirements and better pain scores throughout their postoperative course.

Ketorolac Reduces Spinal Astrocytic Activation and PAR1 Expression Associated with Attenuation of Pain after Facet Joint Injury

“…[25][26][27] Ketorolac, a non-steroidal anti-inflammatory drug (NSAID) with strong analgesic activity, has been used clinically to treat postoperative, inflammatory, and neuropathic pain. [28][29][30][31][32] The primary mechanism of action of ketorolac is by local non-selective inhibition of the activity of cyclooxygenase (COX)-1 and COX-2, which diminishes prostaglandin production, and is associated with a reduction in behavioral sensitivity. [33][34][35] Intra-articular ketorolac injection reduces joint inflammation and postoperative pain in the knee in both clinical and animal models.…”

Effect of Preoperative Rectal Indomethacin on Postoperative Pain Reduction After Open Cholecystectomy

“…[5][6][7][8][9] In addition, decreased opioids side effects, such as nausea and vomiting improved recovery, and shorter hospital stay is another major advantage attributed to the use of NSAIDs before surgery. 10,11 Preoperative NSAID administration can also improve anesthesia through the attenuation of the stress response to endotracheal intubation.…”

Assessment of Sedation During Opioid Administration for Pain Management

“…15,16 Further, multimodal analgesia can result in comparable or greater pain relief than can be achieved with any single analgesic. [17][18][19] Note that the POSS recommends administering a nonsedating nonopioid to excessively sedated patients (see Table 1). A preventive approach is preferred whereby nonopioids are routinely initiated preoperatively or at least at the same time as opioids in the PACU.…”