Ketorolac tromethamine: An oral/injectable nonsteroidal anti-inflammatory for postoperative pain control

The Effectiveness of Ketorolac in Relieving Pain Associated With Root Canal Therapy: A Systematic Review and Meta‐Analysis

“…This observation may be attributed to the pharmacological mechanisms and pharmacokinetics of the drug. Ketorolac primarily functions by inhibiting the cyclooxygenase enzyme involved in arachidonic acid metabolism, thereby reducing prostaglandin synthesis (Fan et al 2025;Redden 1992). Ketorolac demonstrates favorable pharmacokinetic characteristics, including rapid absorption and onset of action.…”

The Effectiveness of Ketorolac in Relieving Pain Associated With Root Canal Therapy: A Systematic Review and Meta‐Analysis

“…This observation may be attributed to the pharmacological mechanisms and pharmacokinetics of the drug. Ketorolac primarily functions by inhibiting the cyclooxygenase enzyme involved in arachidonic acid metabolism, thereby reducing prostaglandin synthesis (Fan et al 2025;Redden 1992). Ketorolac demonstrates favorable pharmacokinetic characteristics, including rapid absorption and onset of action.…”

Sniffing out Endodontic Pain: Use of an Intranasal Analgesic in a Randomized Clinical Trial

“…Clinical trials of ketorolac for controlling pain date back to the early 1990s. These early studies compared ketorolac with common opioids and showed it to be as effective or more effective in relieving postoperative pain (13)(14)(15). Ketorolac quickly found its way into many different pain models.…”

Intra‐Muscular Ketorolac Administered as a Supplemental Analgesic for Removal of Impacted Third Molar Teeth: A Prospective Study

“…Reddan 20 compared ketorolac in combination with opioids, to opioids alone, for the control of pain in those patients undergoing oral surgery on an outpatient basis, and found ketorolac resulted in less opioid consumption. However, in this study, there was a range of surgical procedures performed with no attempt at standardization.…”

The Effectiveness of Ketorolac in Relieving Pain Associated With Root Canal Therapy: A Systematic Review and Meta‐Analysis

“…This observation may be attributed to the pharmacological mechanisms and pharmacokinetics of the drug. Ketorolac primarily functions by inhibiting the cyclooxygenase enzyme involved in arachidonic acid metabolism, thereby reducing prostaglandin synthesis (Fan et al 2025;Redden 1992). Ketorolac demonstrates favorable pharmacokinetic characteristics, including rapid absorption and onset of action.…”

Sniffing out Endodontic Pain: Use of an Intranasal Analgesic in a Randomized Clinical Trial

“…Clinical trials of ketorolac for controlling pain date back to the early 1990s. These early studies compared ketorolac with common opioids and showed it to be as effective or more effective in relieving postoperative pain (13)(14)(15). Ketorolac quickly found its way into many different pain models.…”

Intra‐Muscular Ketorolac Administered as a Supplemental Analgesic for Removal of Impacted Third Molar Teeth: A Prospective Study

“…Reddan 20 compared ketorolac in combination with opioids, to opioids alone, for the control of pain in those patients undergoing oral surgery on an outpatient basis, and found ketorolac resulted in less opioid consumption. However, in this study, there was a range of surgical procedures performed with no attempt at standardization.…”

The Effectiveness of Ketorolac in Relieving Pain Associated With Root Canal Therapy: A Systematic Review and Meta‐Analysis

“…This observation may be attributed to the pharmacological mechanisms and pharmacokinetics of the drug. Ketorolac primarily functions by inhibiting the cyclooxygenase enzyme involved in arachidonic acid metabolism, thereby reducing prostaglandin synthesis (Fan et al 2025;Redden 1992). Ketorolac demonstrates favorable pharmacokinetic characteristics, including rapid absorption and onset of action.…”

Sniffing out Endodontic Pain: Use of an Intranasal Analgesic in a Randomized Clinical Trial

“…Clinical trials of ketorolac for controlling pain date back to the early 1990s. These early studies compared ketorolac with common opioids and showed it to be as effective or more effective in relieving postoperative pain (13)(14)(15). Ketorolac quickly found its way into many different pain models.…”

Intra‐Muscular Ketorolac Administered as a Supplemental Analgesic for Removal of Impacted Third Molar Teeth: A Prospective Study

“…Reddan 20 compared ketorolac in combination with opioids, to opioids alone, for the control of pain in those patients undergoing oral surgery on an outpatient basis, and found ketorolac resulted in less opioid consumption. However, in this study, there was a range of surgical procedures performed with no attempt at standardization.…”