Ketogenic Diet and microRNAs Linked to Antioxidant Biochemical Homeostasis

Cannataro, Roberto; Caroleo, Maria Cristina; Fazio, Alessia; Torre, Chiara La; Plastina, Pierluigi; Gallelli, Luca; Lauria, Graziantonio; Cione, Erika

doi:10.3390/antiox8080269

Cited by 39 publications

(41 citation statements)

References 43 publications

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“…Indeed, even if orally introduced, bioactive dietary factors induce miRNA synthesis, these are packaged into exosomes and released into the bloodstream to act systemically (51). Dietary factors are emerging as anti-inflammatory miRNA promoters able to regulate metabolic functions, inflammation, and oxidation systemically (52)(53)(54)(55). Furthermore, herb extracts may combine antiviral, anti-inflammatory, and antioxidant activity, and tissue-repair properties (56,57) (Figure 1).…”

Section: Can Nutritionally Derived Products Help To Contain/alleviatementioning

confidence: 99%

Coronavirus Disease (COVID-19–SARS-CoV-2) and Nutrition: Is Infection in Italy Suggesting a Connection?

Cena

Chieppa

2020

Front. Immunol.

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Novel coronavirus disease (COVID-19) was declared a global pandemic on March 11, 2020. The outbreak first occurred in Wuhan, Hubei, China, in December 2019 and hit Italy heavily in February 2020. Several countries are adopting complete or partial lockdown to contain the growth of COVID-19 infection. These measures may affect people's mental health and well-being but are necessary to avoid spreading the pandemic. There has been a gradual increase in studies exploring prevention and control measures, and we recommend paying close attention to nutrition, which may contribute to modulating some important consequences of COVID-19 infection, as such pro-inflammatory cytokine storm.

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Section: Can Nutritionally Derived Products Help To Contain/alleviatementioning

confidence: 99%

Coronavirus Disease (COVID-19–SARS-CoV-2) and Nutrition: Is Infection in Italy Suggesting a Connection?

Cena

Chieppa

2020

Front. Immunol.

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“…Bioactive dietary components could have the ability to change miRNA expression, thereby modulating important pathways involved in metabolism [ 20 , 21 , 39 , 40 ]. MiRNAs are involved in the expression of a widespread range of proteins and their consequent effect on metabolic functions and the maintenance of oxidative stress [ 41 ]. Therefore, it seems reasonable to assume that some bioactive compounds present in different foods may modulate the development and progression of certain diseases through miRNA.…”

Section: Discussionmentioning

confidence: 99%

Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity

et al. 2021

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Background: The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). Methods: We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid obesity and its association with the MD and MS. Results: There is an association between the adherence to MD and higher serum levels of mir-590. Mir-590 was lower in those patients who consumed >2 commercial pastries/week. Mir-let7a was lower in those who consumed ≥1 sweetened drinks, in those who consumed ≥3 pieces of fruit/day and in those who consumed less red than white meat. A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. A higher mir-192 was found in those patients who met the triglyceride criterion of MS and in those with type 2 diabetes (T2DM). Conclusions: There is an association between specific serum levels of miRNAs and the amount and kind of food intake related to MD. Mir-590 was positively associated with a healthy metabolic profile and type of diet, while mir-192 was positively associated with a worse metabolic profile. These associations could be suggestive of a possible modulation of these miRNAs by food.

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“…In lung cancer, naringenin biochemical activity inhibits migration and invasion, as well as tumor growth, through the regulation of the microRNA-3619-5p, which belong to a regulating axis with circular RNA FOXM1 and sperm-associated antigen 5 [ 39 ]. Lastly, Curti et al recently demonstrate that naringenin is able to affect the miR-17-3p involved in the control of antioxidant endogenous system [ 40 ]. Using a Caco cell, a well characterized in vitro model which mimics the intestinal barrier, it is demonstrated that single enantiomers of naringenin R and S have similar activity on this miR, while their equimolar racemic mixture does not [ 41 ].…”

Section: Micrornasmentioning

confidence: 99%

Polyphenols in the Mediterranean Diet: From Dietary Sources to microRNA Modulation

et al. 2021

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It is now well established that polyphenols are a class of natural substance that offers numerous health benefits; they are present in all plants in very different quantities and types. On the other hand, their bioavailability, and efficacy is are not always well proven. Therefore, this work aims to discuss some types of polyphenols belonging to Mediterranean foods. We chose six polyphenols—(1) Naringenin, (2) Apigenin, (3) Kaempferol, (4) Hesperidin, (5) Ellagic Acid and (6) Oleuropein—present in Mediterranean foods, describing dietary source and their chemistry, as well as their pharmacokinetic profile and their use as nutraceuticals/supplements, in addition to the relevant element of their capability in modulating microRNAs expression profile.

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Ketogenic Diet and microRNAs Linked to Antioxidant Biochemical Homeostasis

Cited by 39 publications

References 43 publications

Coronavirus Disease (COVID-19–SARS-CoV-2) and Nutrition: Is Infection in Italy Suggesting a Connection?

Coronavirus Disease (COVID-19–SARS-CoV-2) and Nutrition: Is Infection in Italy Suggesting a Connection?

Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity

Polyphenols in the Mediterranean Diet: From Dietary Sources to microRNA Modulation

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