Ketofol (Mixture of Ketamine and Propofol) Administration in Electroconvulsive Therapy

Kayhan, Gülay Erdoğan; Yücel, Aytaç; Çolak, Yusuf Ziya; Özgül, Ülkü; Yologlu, S.; Karlidağ, Rıfat; Ersoy, M. Özcan

doi:10.1177/0310057x1204000214

Cited by 43 publications

(11 citation statements)

References 31 publications

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“…Incidence of hallucination and nausea were lower, although were not statistically signifi cant. Kayhan et al [27], evaluated the effect of a ketaminepropofol combination (ketofol) for electroconvulsive therapy (ECT) on seizure activity, hemodynamic response and recovery parameters compared to propofol alone. The seizure durations in both groups were similar.…”

Section: Discussionmentioning

confidence: 99%

Low-Dose Ketamine and Propofol Combination for Upper Endoscopy in Morbidly Obese Patients

Salem¹

2017

Glob J Anesth

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Aim: The purpose of this randomized double-blinded study is to compare the safety and effi cacy of two different concentrations of ketofol on the intraoperative hemodynamics, respiration, bispectral index values and post-anesthesia recovery profi les in morbid obese patients undergoing upper GI endoscopy. Subjects and methods: Patients were randomly allocated into two groups, group I (k/p 1/2), no = 50, and group II (k/p 1/4), no = 50, after receiving ethics committee approval and informed patient's consent. Patients in group I received bolus dose of ketamine 0.5 mg/kg + propofol 1 mg/kg, and group II received ketamine 0.25 mg/kg + propofol 1 mg/kg, intravenously in separate syringes (dosed ketamine then propofol). Incremental doses, half the fi rst dose of propofol (0.5 mg/kg) were given to get the desired depth of sedation, modifi ed by aiming at bispectral index (BIS) values between 70-80, and when the sedation was considered as inadequate by the endoscopist. The baseline measurements were obtained just before the administration of the study drugs. The primary outcome was emergence reactions (recovery agitation or hallucination) following the procedure. Results: There was no signifi cant difference between group I (k/p 1/2) and group II (k/p 1/4) as regard to demographic data (age, gender and BMI) and procedure duration. Discharge time from postanesthesia care unit (PACU) was prolonged in group I (Mean±SD = 38.34±4.28) compared to group II (Mean±SD = 33.11±4.89), p = 0.0001. The number of patients requiring propofol top-up doses was 20 (40%) in group I compared to 35 (70%) in group II (the low-dose ketamine group), p = 0.004. There was a signifi cant difference in the mean propofol top-up dose between the two groups (30±15 mg in group I and 41±13 mg in group II, p = 0.0002). No signifi cant difference between both groups as regard to BIS values and VAS pain score. Conclusion: The use of ketamine and propofol combination for upper GI endoscopy in morbid obese patients appears to be safe, effective and preserve the hemodynamic and respiratory parameters.

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Section: Discussionmentioning

confidence: 99%

Low-Dose Ketamine and Propofol Combination for Upper Endoscopy in Morbidly Obese Patients

Salem¹

2017

Glob J Anesth

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“…They found that the hemodynamic parameters were stable in the ketofol group. 20 Hashemi et al studied two different concentrations of ketofol in children and reported that recovery time and adverse events were reduced in low ketamine concentration group. 21 Phillips et al studied propofol monotherapy versus ketofol in PSA and concluded that sedation with ketofol was adequate but propofol alone need deep sedation level.…”

Section: Discussionmentioning

confidence: 99%

A randomized comparative study of two different concentrations of ketamine and propofol combination in upper gastrointestinal endoscopy procedures

Salem

2020

Al-Azhar International Medical Journal

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Background: Ketofol is a mixture of ketamine and propofol. It is one of the agents known to achieve procedural sedation and analgesia. Aim of the study: This prospective randomized study compared the effectiveness and safety of two doses of ketofol in morbidly obese patients undergoing diagnostic upper gastrointestinal endoscopy. Methods: The study included 100 adult patients, American Society of Anesthesiologists II and III. The patients were divided into two equal groups; group I in which the ketamine dose equal the propofol dose (k/p 1:1), n=50, and group II in which ketamine dose equal ¼ of the propofol dose (k/p 1:4), n=50. In separate syringes, ketamine 1mg/kg plus propofol 1mg/kg were injected intravenously in group I. In group II, patients are given ketamine 0.25 mg/kg plus propofol 1mg/kg. The bispectral index values, intraoperative hemodynamic changes, respiratory profiles, visual analog scale pain score, and adverse events were recorded. Results: No statistically significant difference between both groups regarding bispectral index values, hemodynamics, respiratory profiles, and visual analog scale pain score. The time needed to discharge patients from the postanesthetic care unit was prolonged in group I (39 min) compared with group II (32 min). Recovery agitation was reported in 5 patients in group I. Conclusion: Both concentrations of ketamine and propofol are effective and safe in the sedation of obese patients. It is recommended to use the combination of ketamine and propofol (k/p 1:4) because this concentration is associated with a short recovery and less psychotomimetic side effects.

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“…Οι Aisworth et al το 2019 συμπεριέλαβαν 18 διπλά τυφλές τυχαιοποιημένες ελεγχόμενες μελέτες από τις οποίες δεν διαπιστώθηκε διαφορά στη βαρύτητα των συμπτωμάτων στο τέλος των συνεδριών ΗΣΘ μεταξύ των ασθενών που έλαβαν κεταμίνη ως αναισθητικό (μόνη ή σε συνδυασμό) και της ομάδας ελέγχου. 25,[27][28][29][30][31][33][34][35][36]38,42,43,[45][46][47][48] Επιπλέον, δεν διαπιστώθηκε ταχύτερη απάντηση στην ΗΣΘ με κεταμίνη σε σχέση με την ΗΣΘ με άλλο αναισθητικό.…”

Section: η κεταμίνη ως αναισθητικό στην ηλεκτροσπασμοθεραπείαunclassified

Electroconvulsive therapy in treatment resistant depression: What is new?

Kaliora¹

2021

Psychiatriki

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Ketofol (Mixture of Ketamine and Propofol) Administration in Electroconvulsive Therapy

Cited by 43 publications

References 31 publications

Low-Dose Ketamine and Propofol Combination for Upper Endoscopy in Morbidly Obese Patients

Low-Dose Ketamine and Propofol Combination for Upper Endoscopy in Morbidly Obese Patients

A randomized comparative study of two different concentrations of ketamine and propofol combination in upper gastrointestinal endoscopy procedures

Electroconvulsive therapy in treatment resistant depression: What is new?

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