Keratosis pilaris and scarring alopecia. Keratosis follicularis spinulosa decalvans

Maroon, Michele; Wb, Tyler; Vj, Marks

doi:10.1001/archderm.128.3.397b

Cited by 15 publications

(11 citation statements)

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“…The loss of the lateral eyebrows in our patient, with associated keratotic follicular papules, is a finding previously observed in patients with KFSD 1,9 , 10 . Eyebrow involvement is classically a feature of keratosis pilaris atrophicans faciei (ulerythema oophryogenes), but scarring alopecia of the scalp rarely occurs in this condition 3 .…”

Section: Discussionsupporting

confidence: 87%

Keratosis follicularis spinulosa decalvans and acne keloidalis nuchae

2005

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A 27-year-old man presented with a 10-year history of scarring alopecia on the vertex of the scalp associated with follicular crusting and pustule formation, and a papular eruption on the posterior neck. Additionally, there was keratosis pilaris on the cheeks, eyebrows and thighs. Histology from the vertex showed scarring with a mixed perifollicular inflammatory infiltrate and foci of acute suppurative folliculitis. With clinical correlation, the diagnosis of keratosis follicularis spinulosa decalvans and concurrent acne keloidalis nuchae was made. The association of keratosis follicularis spinulosa decalvans with acne keloidalis nuchae has not previously been described. The patient responded to treatment with oral isotretinoin 20 mg (0.25 mg/kg) daily for 12 months.

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Section: Discussionsupporting

confidence: 87%

Keratosis follicularis spinulosa decalvans and acne keloidalis nuchae

2005

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“…KPA is a group of diseases characterized by keratotic follicular papules, variable degrees of inflammation and secondary scarring. Traditionally, it is divided into 3 entities: KPAF/UO, AV and KFSD, 2‐6 which are differentiated by lesional distribution and degrees of inflammation and atrophy 2,3,7‐9 . Rand and Baden distinguished the KPA group of disorders from other follicular diseases by onset in infancy, follicular hyperkeratosis and end‐stage scarring.…”

Section: Discussionmentioning

confidence: 99%

“…KFSD is characterized by widespread follicular hyperkeratosis, alopecia of the scalp, eyebrows and eyelashes, and it may transform into scarring alopecia 27,31‐33 . Other characteristics can include atopy, palmoplantar keratoderma, corneal abnormalities and photophobia . Some reports include loss of axillary, pubic or extremity hair, 2,35‐37 with one case resulting in atrophic pitted scars .…”

Section: Discussionmentioning

confidence: 99%

Lichenoid folliculitis: A unifying concept

Turegano

Sperling

2017

J Cutan Pathol

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Skin diseases presenting with keratotic papules, atrophy, cicatricial alopecia and/or "lichenoid" histopathologic changes have been described under at least 30 names. This family of diseases contains 2 subgroups, largely based on clinical features: keratosis pilaris atrophicans (KPA; including keratosis pilaris atrophicans faciei/ulerythema ophryogenes, atrophoderma vermiculata, and keratosis follicularis spinulosa decalvans); and the lichen planopilaris (LPP) subgroup (including LPP, frontal fibrosing alopecia, Graham-Little-Piccardi-Lassueur Syndrome and fibrosing alopecia in a pattern distribution). An interface dermatitis with lichenoid inflammation is characteristic of the LPP group of disorders, but the literature provides scant information about the histopathology of the KPA group. Our experience has been that the 2 subgroups show a unifying histologic similarity as well as considerable clinical overlap. Because these conditions overlap clinically and histologically, we propose that the term lichenoid folliculitis (LF) be used to refer to this group of diseases, thus simplifying cumbersome nomenclature and highlighting the possibility of shared pathogenesis and treatment options.

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“…Good control of inflammation and pustules was achieved in a 12‐year‐old using isotretinoin 0·6 mg kg −1 daily for 20 weeks 247 . Most reports, however, do not show benefit from this treatment 241,243,244,248–250 . Herd and Benton 250 suggest that treatment is only likely to be effective when given during the active phase of the disease, which they feel may explain some of the reported treatment failures with retinoids.…”

Section: Lymphocytic Groupmentioning

confidence: 99%

Management of primary cicatricial alopecias: options for treatment

et al. 2008

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Primary cicatricial alopecias (PCAs) are a poorly understood group of disorders that result in permanent hair loss. Clinically, they are characterized not only by permanent loss of hair shafts but also of visible follicular ostia along with other visible changes in skin surface morphology, while their histopathological hallmark usually (although not always) is the replacement of follicular structures with scar-like fibrous tissue. As hair follicle neogenesis in adult human scalp skin is not yet a readily available treatment option for patients with cicatricial alopecias, the aim of treatment, currently, remains to reduce symptoms and to slow or stop PCA progression, namely the scarring process. Early treatment is the key to minimizing the extent of permanent alopecia. However, inconsistent terminology, poorly defined clinical end-points and a lack of good quality clinical trials have long made management of these conditions very challenging. As one important step towards improving the management of this under-investigated and under-serviced group of dermatoses, the current review presents evidence-based guidance for treatment, with identification of the strength of evidence, and a brief overview of clinical features of each condition. Wherever only insufficient evidence-based advice on PCA management can be given at present, this is indicated so as to highlight important gaps in our clinical knowledge that call for concerted efforts to close these in the near future.

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Keratosis pilaris and scarring alopecia. Keratosis follicularis spinulosa decalvans

Cited by 15 publications

References 0 publications

Keratosis follicularis spinulosa decalvans and acne keloidalis nuchae

Keratosis follicularis spinulosa decalvans and acne keloidalis nuchae

Lichenoid folliculitis: A unifying concept

Management of primary cicatricial alopecias: options for treatment

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