1941
DOI: 10.1001/archderm.1941.01490200003001
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Keratosis Follicularis (Darier's Disease)

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1942
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Cited by 61 publications
(8 citation statements)
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“…Because of its use in Darier's disease, 23 vitamin A was used in Grover's disease in a relatively high dose (150 000 IU/day) in the early 1980s 24 and this led subsequently to the synthetic retinoids: etretinate, acitretin and isotretinoin. 25,26 The literature contains many examples of retinoid use that testifies to its presumed effectiveness.…”
Section: Treatmentmentioning
confidence: 99%
“…Because of its use in Darier's disease, 23 vitamin A was used in Grover's disease in a relatively high dose (150 000 IU/day) in the early 1980s 24 and this led subsequently to the synthetic retinoids: etretinate, acitretin and isotretinoin. 25,26 The literature contains many examples of retinoid use that testifies to its presumed effectiveness.…”
Section: Treatmentmentioning
confidence: 99%
“…Vitamin A deficiency is known to result in squamous metaplasia of a variety of epithelia that is often associated with increased cell proliferation and hyperkeratosis in the skin (Peck et al, 1949). From studies of vitamin A-deficient animals and observation of vitamin A-deficient human infants, it was suggested that vitamin A deficiency gives rise to follicular keratoses resembling Darier's disease or pityriasis rubra pilaris (Peck and DiGiovanna, 1994).…”
mentioning
confidence: 99%
“…More recently, a number of synthetic RA analogs with enhanced therapeutic efficacy have been developed (Peck and DiGiovanna, 1994;Roos et al, 1998;Shroot et al, 1999;Blaner, 2001;Zouboulis, 2001). It is important to emphasize that the skin has both a physiologic requirement for RA and responds to pharmacologic doses of natural or synthetic retinoids that are effective for treating patients with skin disease (Peck et al, 1949).…”
mentioning
confidence: 99%
“…The cause of the disease is unknown. The possibility of a disturbed vitamin A metabolism in DD has been discussed for years [7,14]. Vitamin A has also been claimed to have a beneficial effect on DD [1,14].…”
mentioning
confidence: 99%
“…The possibility of a disturbed vitamin A metabolism in DD has been discussed for years [7,14]. Vitamin A has also been claimed to have a beneficial effect on DD [1,14]. In recent years the aromatic vitamin A analogue, etretinate (Ro 10-9359) has been reported to be the remedy of choice in DD [2,3,6,10,11,16,17].…”
mentioning
confidence: 99%