Keratoacanthomas arising in hypertrophic lichen planus. A case report

Giant keratoacanthoma arising in hypertrophic lichen planus

“…Similar to this case, the two previous reports of keratoacanthoma development both occurred on the lower leg in association with hypertrophic lichen planus 14,15 . The initial report described three small keratoacanthomas of unspecified size and the latter a solitary 2‐cm nodule.…”

The significance of eosinophils in hypertrophic lichen planus

“…In addition to that, recent reports have shown a considerable overlap between hypertrophic LP and keratoacanthoma in terms of both histopathologic features and P53 and MIB‐1 expression . These findings along with the prior reports of cases of keratoacanthoma arising in hypertrophic LP provide further evidence for the importance of making accurate diagnosis of hypertrophic LP …”

“…22 These findings along with the prior reports of cases of keratoacanthoma arising in hypertrophic LP provide further evidence for the importance of making accurate diagnosis of hypertrophic LP. 10,11 In summary, this study provides evidence of the variable morphological appearance of hypertrophic LP. In order to provide evidence-based patient care and counseling, hypertrophic LP should be considered in the differential diagnosis of lichenoid dermatitis with eosinophils.…”

Keratoacanthoma arising in hypertrophic lichen planus

“…We have only been able to find one previous report describing a woman who developed three KAs in HLP of 1 year’s duration. 3 In contrast, our patient was a man who developed only one KA in HLP of more than 20 years’ duration. In both cases, pathogenetic mechanisms such as chronic inflammation, chronic corticosteroid therapy and chronic mechanical trauma should be considered.…”