Keratoacanthoma Versus Squamous-Cell Carcinoma

Keratoacanthoma within a superficial spreading malignant melanoma in situ

“…Kopf (4) enumerates a large series of cases of keratoacanthomas arising from or engrafted on a number of skin disorders (Table 1), but malignant melanoma is not among them. In the literature, there are references to keratoacanthomas that have been considered as secondary to topical applications of several products, including tar and oil products (5) and podophylin (6). In this regard, the 5-fluorouracil ointment used by the patient might be considered as an etiologic factor, but, contrarily, topical applications of this chemotherapeutic agent have demonstrated improvement of keratoacanthoma (7).…”

Intradermal Triamcinolone Therapy of Keratoacanthomas

“…Ereaux 4 stated, "We have yet to discover a histological yardstick for easy measurement of keratoacanthomas which will enable us to differentiate with certainty benign and malignant process." Mont¬ gomery 10 reports all his cases "compatible with" rather than unequivocally keratoacan¬ thomas and suggests that clinical findings corroborate the final diagnosis.…”

Keratoacanthoma

“…3 The fact that these lesions were not reported as a definite entity in this country prior to 1954, coupled with the flood of reports in the literature 4 picture of keratoacanthoma is that of a papule on an exposed surface, which pro¬ gresses into a rapidly growing, elevated, dome-shaped lesion, having a central crater filled with a keratin plug. The base and sur¬ rounding skin may show a ring or halo of inflammation, but usually no inflammatory zone is present.…”