Keratoacanthoma in Kauai, Hawaii. The first documented incidence in a defined population

Decreased incidence of nonmelanoma skin cancer in patients with type 2 diabetes mellitus using insulin: a pilot study

“…[4][5][6][7] Separate studies demonstrated that 100% of a defined population in Kanai, Hawaii had skin cancer by the age of 85 years. [8][9][10][11][12][13][14][15] In fact, the majority of skin cancers are found in people over the age of 60; therefore, age is also a risk factor for the development of skin cancer. 3 While the correlation between aged epidermis and NMSC is obvious, the mechanism responsible for this relationship remains obscure.…”

Keratoacanthoma: A Clinico-Pathologic Enigma

“…86 The typical occurrence of KA on sun-exposed areas in older persons suggests that UVR is of great etiologic significance in the common solitary type of KA. 87 In the United Kingdom and Australia, the incidence of both KA and SCC shows parallel elevations with increased solar exposure. 1,17,18 Likewise, the occurrence of KAs with other solar-induced tumors in patients with xeroderma pigmentosum is suggestive.…”

Periocular squamous cell carcinoma

“… 38 It is relatively uncommon in the periocular area with SCC occurring five times more frequently 38–40 . As it may exhibit local tissue destruction, invasive behaviour with infiltration into underlying tissues or perineural invasion (PNI), 41 many regard keratoacanthoma as a form of low‐grade SCC with a strong propensity for regression 42 . In addition, invasive SCC may also present with rapid growth like keratoacanthoma, making it impossible to distinguish between the two entities clinically.…”