Keratoacanthoma centrifugum marginatum: A diagnostic and therapeutic challenge

Keratoacanthoma centrifugum marginatum associated with mechanical trauma: Response to acitretin—A case report and review of the literature

“…In KCM, lesions can reach up to 20 cm in diameter 1 . Unlike traditional KA, KCM does not show a tendency for spontaneous resolution 4 .…”

“…KA is rapidly growing tumor, originating in follicular infundibular epithelium, characterized by dome shaped, skin colored to reddish papule, with central crater filled with keratin 1 . KA is usually solitary 4 .…”

“…Keratoacanthoma centrifugum marginatum (KCM) is an extremely rare variant of keratoacanthoma (KA). KCM differs from KA clinically and by lacking some histological features of classic KA 1 . Keratoacanthoma centrifugum was first described by Miedzinski and Kozakiewics in 1962, the term KCM was coined by Belisario in 1965; since then around 50 cases have been reported worldwide 2,3 .…”

“…It shows no tendency for spontaneous resolution. KCM is more frequent on chronic sun‐exposed areas, usually in white‐skinned adult patients in the fifth or sixth decade of life, mostly in men 1,4 . Although locally destructive, it is generally accepted that KCM is a benign entity 4 .…”

Keratoacanthoma Centrifugum Marginatum (KCM) after photodynamic therapy with good response to oral retinoids and topical 5‐fluorouracil

“…It is considered a benign neoplasm without tendency to deep invasion. Cases with distant metastasis have not been reported (Dominiak et al, 2016). Although some cases have been related with chronic sun exposure, smoking, exposure to chemical carcinogens (Georgescu et al, 2017), or traumatisms (Borkhatariya et al, 2011), its etiology is unknown.…”