Keratoacanthoma. Association with basal and squamous cell carcinoma

Multiple keratoacanthomas: association with deficient cell mediateted immunity

“…Our patient has had a particularly severe form of keratoacanthoma with mutilation ofthe left nostril and marked atrophic scars. No squamous or basal cell carcinomas have arisen from the lesions during the course of the disease, as was reported by Burge & Winkelmann (1969) in a case with a solitary tumour treated with methotrexate.…”

Treatment of Keratoacanthomas with Curettage

“…In this connection, the diagnostic problems associated with keratoacanthomas should be borne in mind. The literature contains numerous examples of faulty diagnosis, where tumors which were considered to be typical kerato-acanthomas both clinically and histologically, later turned out to be squam ous cell carcinomas and, in some cases, even metastasizing [1,2,3,5,6,11]. On the basis of such experiences, many of the authors point out that patients with suspected keratoacanthoma should always be examined by specially trained dermatologists and histopathologists, and they should also be checked at very frequent intervals during the posttreatment period.…”

Pke-Cancer and the Skin

“…Inclusion bodies have also been found in kerato-acanthomata (35,259), and these lesions can be locally recurrent and destructive, especially the inultiple familial variant (144). Exposure to oils, other irritants, and to trauma have been followed by squamous carcinomata in these " benign " lesions (38,145,214). Recurrence is always a possibility with keratoacanthomata, and even allowing for the, imperfections of some biopsies, a potential for malignancy inust be suspected.…”