KCNH6 channel promotes insulin exocytosis via interaction with Munc18-1 independent of electrophysiological processes
Hao Wang,
Qi Li,
Ying-Chao Yuan
et al.
Abstract:Glucose-stimulated insulin secretion (GSIS) in pancreatic islet β-cells primarily relies on electrophysiological processes. Previous research highlighted the regulatory role of KCNH6, a member of the Kv channel family, in governing GSIS through its influence on β-cell electrophysiology. In this study, we unveil a novel facet of KCNH6's function concerning insulin granule exocytosis, independent of its conventional electrical role. Young mice with β-cell-specific KCNH6 knockout (βKO) exhibited impaired glucose … Show more
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