Kawasaki-Syndrom

Jakob, André

doi:10.1007/s00112-016-0048-4

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…Kawasaki Disease (KD) is a generalized vasculitis in children, still of unknown etiology [ 1 ]. Other than boys < 5 years being most often affected 1 , its incidence also reveals a geographic and ethnic susceptibility, as children of Asian origin are affected more often than those of Caucasian origin: the highest incidence in children aged 0–4 years is in Japan, with 359/100,000 in 2018 [ 2 ], whereas the annual incidence in Germany is 7.2/100,000 [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, KD presents with persistent fever, cervical lymphadenopathy, non-exudative conjunctivitis, enanthema, polymorphous exanthema and reddened palms and soles, with subsequent scaling on the toes and fingers. Coronary artery aneurysms (CAA) are KD’s most feared complication, with a strong impact on long-term morbidity; they still occur in approximately 5% of all children who undergo intravenous immunoglobulin (IVIG) treatment [ 1 , 4 ], and in even 25% of untreated children [ 4 ]. Its acute clinical presentation already shows that the inflammatory process is not only limited to the coronary arteries, but is probably attributable to vascular changes in various tissues and organs, e.g., the gastrointestinal tract (pain, vomiting, diarrhea), meninges (aseptic meningitis) or lung (interstitial pneumonitis) [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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KD Diagnosis Does Not Increase Cardiovascular Risk in Children According to Dynamic Intima–Media Roughness Measurements

König

Ullmann

Pastor-Villaescusa

et al. 2022

JCM

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Background: Kawasaki Disease (KD) is a generalized vasculitis in childhood with possible long-term impact on cardiovascular health besides the presence of coronary artery lesions. Standard vascular parameters such as carotid intima–media thickness (cIMT) have not been established as reliable markers of vascular anomalies after KD. The carotid intima–media roughness (cIMR) representing carotid intimal surface structure is considered a promising surrogate marker for predicting cardiovascular risk even beyond cIMT. We therefore measured cIMR in patients with a history of KD in comparison to healthy controls to investigate whether KD itself and/or KD key clinical aspects are associated with cIMR alterations in the long-term. Methods: We assessed cIMR in this case-control study (44 KD, mean age in years (SD); 13.4 (7.5); 36 controls, mean age 12.1 (5.3)) approximately matched by sex and age. Different clinical outcomes such as the coronary artery status and acute phase inflammation data were analyzed in association with cIMR values. Results: When comparing all patients with KD to healthy controls, we detected no significant difference in cIMR. None of the clinical parameters indicating the disease severity, such as the persistence of coronary artery aneurysm, were significantly associated with our cIMR values. However, according to our marginally significant findings (p = 0.044), we postulate that the end-diastolic cIMR may be rougher than the end-systolic values in KD patients. Conclusions: We detected no significant differences in cIMR between KD patients and controls that could confirm any evidence that KD predisposes patients to a subsequent general arteriopathy. Our results, however, need to be interpreted in the light of the low number of study participants.

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Section: Introductionmentioning

confidence: 99%