Kaposi Sarcoma complicating systemic lupus erythematosus treated with immunosuppression

Iatrogenic colorectal Kaposi sarcoma complicating a refractory ulcerative colitis in a human immunodeficiency negative-virus patient

“…Iatrogenic KS has been described in kidney and liver transplant recipients and also auto-immune diseases [5, 6]. KS of gastrointestinal tract is rarely seen in the developed countries.…”

Kaposi's sarcoma: aetiopathogenesis, histology and clinical features

“…Furthermore, all three of them have been associated with DNA viruses (EBV, HHV‐8 and human papillomaviruses, respectively), characterized by oncogenicity and high immunogenicity 66,67 . In particular, KS has been observed during the course of immunosuppressive therapy in patients with disorders of the immune system, such as lupus erythematosus, plasma cell dyscrasia, thymoma, polymyositis and temporal arthritis 68,69 . Regression of KS nodules has been reported following decrease or discontinuation of the immunosuppressive therapy 70 .…”

“…There are also reports of KS developing after the use of immunosuppressive agents in the treatment of a variety of autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, pemphigus vulgaris or pemphigoid, temporal arteritis and haemolytic anaemia 68,69,170 …”

Malignancies in the acquired immunodeficiency syndrome

“…The disease was reported in renal transplant recipients, particularly those requiring marked immunosuppressive therapy (Akhtar et al, 1984;Harwood et al, 1979;Myers et al, 1974). Other patients receiving immunosuppressive drugs, including a patient with systematic lupus erythematosus (Klein et al, 1974) and a patient with myasthenia gravis (Ulbright and Santa Cruz, 1981), have developed Kaposi's sarcoma. It has also been described in a number of other disorders of the immune system, including immunodeficiencies, paraproteinemias, polymositis, and pemphigus (Dantzig, 1974;Law, 1974;Safai, 1984;Ulbright and Santa Cruz, 1981).…”