Kaposi's Varicelliform Eruption

Ruchman, Isaac V.

doi:10.1001/archderm.1947.01520120134015

Cited by 41 publications

(5 citation statements)

References 13 publications

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“…This may account for the apparent lack of virus-neutralizing antibodies initially, with a rise in titre during convalescence (Ruchman et al, 1947). This is illustrated by Case 2, in which there was -a presumed maximum possible "incubation" period of seven days, during which the was apparently quite well.…”

Section: Discussionmentioning

confidence: 97%

“…In a review of the literature, Ruchman et al (1947) are normally sporadic, although epidemics occur in dermatological wards (McLachlan and Gillespie, 1936;Esser, 1941), and have been reported in paediatric and burns units (Nimpfer, 1936;Sims and French, 1948), indicating high infectivity to susceptible persons. Eczema herpeticum may be suspected in the absence of vaccination or known contacts.…”

Section: Discussionmentioning

confidence: 99%

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The Herpes Simplex Virus in Infantile Eczema

Barrow¹

1954

BMJ

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

The Herpes Simplex Virus in Infantile Eczema

Barrow¹

1954

BMJ

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“…Somit stand für ihn fest, dass die "Pustulosis acuta varioliformis" eine "herpetische Manifestation bei exsudativer Diathese" ist [56]. Bereits 1947 wurde mittels serologischer Untersuchungen ein Antikörpertiteranstieg gegen Herpesviren bei Patienten mit Eczema herpeticatum und damit auch ein serologischer Hinweis auf die Ätiologie des Eczema herpeticatum gefunden [52]. Im Jahr 1952 konnte schließlich bei einem betroffenen Erwachsenen ein Herpesvirus als Erreger des Eczema herpeticatum nachgewiesen werden [31].…”

Section: Historischesunclassified

Eczema herpeticatum

Wetzel

Wollenberg

2004

Hautarzt

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Patients affected by atopic dermatitis tend to develop viral infections. Probably the most feared complication of atopic dermatitis is eczema herpeticum, a disseminated infection with herpes simplex virus. A monomorphic eruption of dome-shaped blisters, pustules and erosions in the eczematous skin lesions along with severe systemic illness leads to the diagnosis. The clinical diagnosis may be confirmed by polymerase chain reaction, viral culture, electron microscopy with negative staining, Tzanck test, immunofluorescence tests or serology. While intravenous acyclovir is still regarded as standard treatment of eczema herpeticum, several recently-developed antiviral drugs provide therapeutic options.

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“…all other stables, one HSV-1 strain was responsible for all HG cases in that stable (Table 2 and data supplements B-G). Table 2) was significantly higher (data supplement H) than the BgK L RF of 27 % in the general population in Japan .In seven of the 22 (32 %) HG cases, eczematous lesions with systemic illness were observed and these cases were diagnosed as KVE (also called eczema herpeticum) (Kramer et al, 2004;Marcus et al, 2005;Ruchman, 1954) (Table 2). All HSV-1 isolates from these KVE cases were BgK L (Table 2).…”

mentioning

confidence: 97%

“…In seven of the 22 (32 %) HG cases, eczematous lesions with systemic illness were observed and these cases were diagnosed as KVE (also called eczema herpeticum) (Kramer et al, 2004;Marcus et al, 2005;Ruchman, 1954) (Table 2). All HSV-1 isolates from these KVE cases were BgK L (Table 2).…”

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confidence: 99%

Analysis of herpes simplex virus type 1 restriction fragment length polymorphism variants associated with herpes gladiatorum and Kaposi's varicelliform eruption in sumo wrestlers

Ban

Asano²,

Ozawa

et al. 2008

Journal of General Virology

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The geographical distribution of herpes simplex virus type 1 (HSV-1) restriction fragment length polymorphism (RFLP) variants BgK L and BgO L and the high relative frequency (RF) of BgK L in orolabial lesions has led to a dispersion-replacement hypothesis for these variants. The pathogenic properties of HSV-1 variants in mice and professional sumo wrestlers were examined here. The wrestlers herpes gladiatorum (HG) was caused by primary and non-primary HSV-1 infections and recurred in many wrestlers. HSV-1 neutralizing antibody titres in sera from wrestlers who did not develop HG were relatively high. HG was caused by distinct HSV-1 variants and strains from wrestlers living in the same sumo stable. The BgK L RF was significantly higher in HG cases, particularly in those with Kaposi's varicelliform eruption. These data indicated that reactivation and transmission of latent HSV-1 infections, especially BgK L , occurred frequently among wrestlers and was caused by severe skin damage. These results support the BgK L dispersion hypothesis.Herpes simplex virus type 1 (HSV-1) variant BgK L is a restriction fragment length polymorphism (RFLP) variant (Ozawa et al., 1988(Ozawa et al., , 1989a caused by loss of the BglII cleavage site between the BglII K and Q/13 fragments . BgK L is a good surrogate marker for the HSV-1 multiple mutant BgK L :SaCFJ M :SaE L :SaGH M :KpM S , where SaCFJ M denotes loss of SalI fragments C, F and J, SaE L denotes a larger SalI L fragment, SaGH M denotes loss of SalI G and H fragments and KpM S denotes a smaller KpnI M fragment Ozawa et al., 2006). The prevalence of BgK L in HSV-1 clinical isolates, referred to as its relative frequency (RF), is 27 % in Japan (Ozawa et al., 2006). Another HSV-1 RFLP variant BgO L (Ozawa et al., 1989b) has lost the BglII cleavage site between the BglII Q/ 13 and O fragments . It has been proposed that BgK L spread and replaced BgO L in Japan, based on the geographical distribution profiles of BgK L and BgO L Ozawa et al., 1989bOzawa et al., , 2006 and the high RF of BgK L in orolabial infections .In the present study, we compared the pathogenic and epidemiological properties of HSV-1 BgK L , BgO L and nonBgK L :non-BgO L variants in mice and sumo wrestlers with herpes gladiatorum (HG). Central nervous system (CNS) destruction is a major consequence of experimental murine disease induced by HSV-1 (Dix et al., 1983b; Goel et al., 2002;Mao & Rosenthal, 2003;Richards et al., 1981;Roizman & Knipe, 2001). HG has been documented among wrestlers and rugby players (Anderson, 2003;Becker, 1992;Belongia et al., 1991;De Bernardo, 1992;Turbeville et al., 2006;White & Grant-Kels, 1984 et al., 1990;Dix et al., 1983aDix et al., , 1983bMao & Rosenthal, 2003;Richards et al., 1981) and mutants (Roizman & Knipe, 2001).Clinical specimens and HSV-1 isolates from sumo wrestlers, described previously by Asano et al. (1994) et al., 1994) and HSV-2 was isolated from another wrestler (data not shown). Virus isolates were propagated on Vero cell (Yasumura & Kawakita, 1988) monolayers...

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Kaposi's Varicelliform Eruption

Cited by 41 publications

References 13 publications

The Herpes Simplex Virus in Infantile Eczema

The Herpes Simplex Virus in Infantile Eczema

Eczema herpeticatum

Analysis of herpes simplex virus type 1 restriction fragment length polymorphism variants associated with herpes gladiatorum and Kaposi's varicelliform eruption in sumo wrestlers

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