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“…These data allow to suppose that these cells revealed certain protective mechanisms against AFP cytotoxicity. It may be suggested that cytokine and growth factor secretion by these cells [24,25,31,[46][47][48][49][50] affects their AFP sensitivity (table 1), and that paracrine and autocrine pathways possibly modulate the cellular response to AFP [30,47]. These results imply that the response to AFP represents the integrated sum of multiple separately regulated events which are differently modulated by various combinations of cytokines or growth factors.…”
Section: Discussionmentioning
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“…These data allow to suppose that these cells revealed certain protective mechanisms against AFP cytotoxicity. It may be suggested that cytokine and growth factor secretion by these cells [24,25,31,[46][47][48][49][50] affects their AFP sensitivity (table 1), and that paracrine and autocrine pathways possibly modulate the cellular response to AFP [30,47]. These results imply that the response to AFP represents the integrated sum of multiple separately regulated events which are differently modulated by various combinations of cytokines or growth factors.…”
Section: Discussionmentioning
“…Growth promotion by AFP in different types of cells was also reported [22,23]. Growth factors and oncofetal proteins, such as AFP, are typically present during the development of certain types of cancer [24,25]. AFP is expressed by hepatoma [26] and breast cancer cell lines [15,27], which simultaneously produce and secrete a variety of growth factors, including TGF-·, TGF-ß [20,21], insulin-like growth factor-· (IGF-·) and platelet-derived growth factor (PDGF) [28][29][30].…”
Section: Introductionmentioning
“…The chronic administration (Ͼ8 months) of low-dose IFN-␣ to patients with highly vascularized malignanices has got some therapeutic benefit. 13,31 This may be because the inhibition of angiogenesis requires continuous application of agents for a longer period. Our findings show that IFN-␣ reduced microvessel formation in nude mice corneas.…”
Section: Discussionmentioning
“…IFN-a2b has been widely used, alone or in combination with other agents, in order to treat a variety of neoplasms including melanoma, renal cell carcinoma and transitional cell carcinoma. IFN-a treatment of patients with Kaposi's sarcoma showed in 40% significant regression [24]. Chronic administration of IFN-a2b has also led to the regression of life-threatening hemangiomas of infancy [26] and malignant hemangiopericytomas [25].…”
Section: Discussionmentioning
“…Recent clinical observations suggest a role of IFN-a2b in the inhibition of angiogenesis. The chronic systemic administration of IFN-a2b to patients with Kaposi's sarcoma [24], malignant hemangiopericytoma [25], and life-threatening hemangiomas of infancy [26] resulted in regression of these highly vascularized tumors. Systemic IFN-a2b administration has also been proved effective in decreasing angiogenesis and tumor growth of human bladder cancer 253J B-V cells in an orthotopic athymic mouse model [27].…”
Section: Introductionmentioning