Kaposi's sarcoma in HIV-negative homosexual men

Friedman-Kien, AlvinE.; Saltzman, B; Cao, Yunzhen; Nestor, MarkS.; Mirabile, Michael; Li, Jian Jun; Peterman, ThomasA.

doi:10.1016/0140-6736(90)90041-3

Cited by 179 publications

(57 citation statements)

References 5 publications

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“…The high male to female ratio usually described in this disease and the recent report of KS in HIV sero-negative homosexual men (Friedman-Kien et al, 1990) raise the possibility that KS has always been associated with homosexuality. However, the sex ratio of registered cases in England and Wales was close to unity and no male diagnosed during 1971-1980 who died was single.…”

Section: Discussionmentioning

confidence: 99%

“…The reported occurrence of KS in homosexual men without HIV infection (Friedman-Kien et al, 1990) raises the possibility that KS may be associated with homosexuality independently of HIV infection. If this is so it might account for the adult male excess of pre-AIDS KS. In comparison to AIDS-related KS, the epidemiological features of non-AIDS related KS in industrialised countries have been little studied.…”

mentioning

confidence: 99%

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Kaposi's sarcoma in England and Wales before the AIDS epidemic

Grulich

Beral²,

Swerdlow³

1992

Br J Cancer

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Summary The epidemiological features of Kaposi's Sarcoma (KS) incidence in England and Wales in the period [1971][1972][1973][1974][1975][1976][1977][1978][1979][1980] (Bluefarb, 1957), but no population-based statistics exist.In Central and East Africa, KS has long been a common tumour, accounting for more than 10% of all malignancies in males in some countries (Cook et al., 1971). Before AIDS, the sex ratio in Africa was near to 1: 1 in children, but in adults over 10 males to each female were affected (Olweny, 1984).The AIDS-associated epidemic of KS in industrialised countries has epidemiological features which point to a transmissible agent, spread by sexual contact, plus HIV-mediated immunodeficiency, as the likely cause of this neoplasm (Beral et al., 1990 expected rates. Country of birth was unknown for four males and nine females with KS and these were excluded from calculation of standardised registration ratios. Confidence intervals for standardised registration ratios were calculated from tables of multipliers (exact limits) for estimating SMRs (Breslow & Day, 1982 (underlying and contributory) were obtained from extracts of death certificates of these individuals. The proportion of these people who were single in the two time periods was calculated and the difference in these proportions tested for significance using Fisher's exact test. In males, the proportions were adjusted for age differences by applying the England and Wales population 5 year age specific proportions of men who were single at the 1981 census to calculate expected numbers of single men in both time periods. The observed distribution of males who were single between the two time periods was then compared with the expected distribution under a null hypothesis of no difference in age-adjusted marital status between the two time periods, and tested for significance using the binomial distribution.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Kaposi's sarcoma in England and Wales before the AIDS epidemic

Grulich

Beral²,

Swerdlow³

1992

Br J Cancer

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“…However, evidence suggests that HIV itself is not the direct cause. KS has been reported in sexually active homosexual patients who have consistently remained HIV sero negative (Friedman-Kien et al, 1990). As mentioned, HIV sero positive homosexuals tend to get KS, but drug addicts do not.…”

Section: Infectious Agentsmentioning

confidence: 96%

Kaposi's sarcoma

Dalgleish¹

1991

Br J Cancer

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“…Several clinicopathological variants of KD have been reported [7,12,18], and include: 1) classic KD in Mediterranean people; 2) endemic KD in Africa; 3) epidemic KD in patients with the acquired immune deficiency syndrome (AIDS-KD); 4) KD with immunosuppression in HIV-Ab-negative patients (organ transplantation, immunosuppressive drugs, lymphomas...); and 5) KD in homosexual HIV-Ab negative patients in the absence of immunosuppression. The classic form is rarely lifethreatening and visceral involvement is unusual, thus the prognosis is generally good.…”

Section: Discussionmentioning

confidence: 99%