Kaposi's sarcoma in a patient with dermatomyositis receiving immunosuppressive therapy

Weiss, V. C.

doi:10.1001/archderm.118.3.183

Cited by 13 publications

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“…Among soft tissue tumors, only Kaposi's sarcoma has been reported in association with dermatomyositis. However, this tumor is believed to arise as a complication of immunosuppressive therapy for dermatomyositis rather than as the inciting malignancy (4, 5).…”

Section: Differential Diagnosismentioning

confidence: 99%

Lectins detect changes of the glycosylation status of plasma membrane constituents during late apoptosis

et al. 2006

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Background: Mechanisms governing the normal resolution processes of inflammation are poorly understood, yet their elucidation may lead to a greater understanding of the pathogenesis of chronic inflammation. The removal of apoptotic cell material and their potentially histotoxic contents is a prerequisite of resolution. Engulfment by macrophages is an important disposal route, and changes in the apoptotic cells that are associated with their recognition by macrophages are the subject of this report. Methods: Apoptosis and necrosis in primary cells and cell lines were induced by various stimuli. The binding profile of 23 different lectins for vital, apoptotic, and necrotic cells were analyzed by flow cytometry. Results: We observed that lectins were able to attach to the cell surfaces of vital and dying cells. Some lectins exhibited membrane destructive properties and, consecutively, changed the morphology of the cells as detected by flow cytometry. Other lectins did not show differences in their binding to viable and apoptotic cells. Those lectins were, therefore, not used for analyses of surface changes. The lectins Griffonia

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Section: Differential Diagnosismentioning

confidence: 99%

Lectins detect changes of the glycosylation status of plasma membrane constituents during late apoptosis

et al. 2006

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“…KS has also been seen following immunosuppressive therapy for aplastic anemia, 15 idiopathic thrombocytopenic purpura, 27 hemolytic anemia, 28 asthma, 14,19 nephrotic syndrome, 19 polymyalgia rheumatica, 19 polymyositis, 29 dermatomyositis, 30 rheumatoid arthritis, 9,19 systemic lupus erythematosus, 31 and temporal arteritis 32 . KS has also occurred following immunosuppressive therapy (prednisone and/or azathioprine) for another immunobullous disease other than pemphigus, bullous pemphigoid 19,33,34 …”

Section: Discussionmentioning

confidence: 99%

Pemphigus and Kaposi's Sarcoma

Kaplan¹,

Israel²,

Ahmed³

1989

The Journal of Dermatologic Surgery and Oncology

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A 77-year-old woman developed Kaposi's sarcoma (KS) during prednisone therapy for pemphigus foliaceus. There are 7 prior reports in the literature of KS occurring in association with pemphigus. There are multiple reports of KS occurring in patients without pemphigus who are immunosuppressed either by malignancy or by chemotherapy for various disorders. Although the relationship between KS and pemphigus is a real one, KS is more likely related to therapeutically induced immunosuppression in certain predisposed individuals rather than primarily to pemphigus itself.

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Tumorous swelling on the back

Shrivastava¹,

Khanna²,

Metgud³

et al. 2011

Arthritis Care & Research

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A 29-year-old man with a painless mass on his back. History of the present illnessThe patient had noticed a painless mass over his right midback 2 years earlier. The mass had increased gradually in size. He had no history of fever, weight loss, anorexia, back pain, or similar lesions at any other site on his body. The overlying skin did not appear to be involved, and there was no history of any injury, injection, or surgical procedure on that site. There was no sensory loss or burning or tingling over or around the mass lesion, nor a history of chest pain, cough, hemoptysis, or breathlessness.Examination revealed a well-demarcated mass of moderate firmness that was approximately 7 ϫ 5 cm 2 in dimension. There was no erythema or tenderness to suggest inflammation. There was no spinal tenderness or gibbus, and scapular movements were not restricted. The remainder of the physical examination was unremarkable. Spine radiographs did not reveal any vertebral damage to suggest Pott's spine.Ultrasonography revealed a localized intramuscular abscess on the right scapular area. The patient was subsequently lost to followup for 1 year, during which time he underwent multiple incision and drainage procedures of the presumed abscess at other clinics. However, the lesion did not resolve. Cultures of the pus-like material exuded during abscess drainage were negative on several occasions.When the patient returned to our clinic, the mass had grown significantly in size and now occupied nearly twothirds of the right side of his back and the side of his trunk ( Figures 1A and B). The mass was firm, nontender, and nearly oblong, with few fluctuant areas. It was difficult to determine if the tumor was fixed to underlying structures, but the overlying skin was not tethered. Shoulder girdle movement and chest expansion were nearly normal. There were no enlarged regional lymph nodes. There was no fever and a complete review of systems was otherwise noncontributory. Medical historyThe patient had been diagnosed with dermatomyositis 7 years before presentation with the mass. His dermatomyositis had been characterized by polyarthritis, gradually progressive proximal muscle weakness, and ulcers over both elbows. There was no history of photosensitivity, malar rash, cough, dyspnea, dysphagia, or dysphonia. Examination had revealed a classic Gottron's sign over the dorsal surfaces of his metacarpal, proximal interphalangeal, and distal interphalangeal joints; punched out ulcers over both elbows; and proximal muscle weakness.The patient's muscle enzymes (creatine kinase, lactate dehydrogenase, and aspartate aminotransferase) were elevated more than 4-fold at presentation, accompanied by elevations in the erythrocyte sedimentation rate and C-reactive protein concentration. An enzyme immunoassay for antibodies to the human immunodeficiency virus was negative, as were assays for antinuclear antibodies and antiMi2 antibodies. Electrodiagnostic studies and the result of a muscle biopsy confirmed the diagnosis of dermatomyositis.The patient's elbow...

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Kaposi's sarcoma in a patient with dermatomyositis receiving immunosuppressive therapy

Cited by 13 publications

References 0 publications

Lectins detect changes of the glycosylation status of plasma membrane constituents during late apoptosis

Lectins detect changes of the glycosylation status of plasma membrane constituents during late apoptosis

Pemphigus and Kaposi's Sarcoma

Tumorous swelling on the back

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