Kaposi's sarcoma after immunosuppressive therapy with prednisone

Hoshaw, R. A.

doi:10.1001/archderm.116.11.1280

Cited by 19 publications

(6 citation statements)

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“…Although Kaposi's sarcoma can occur after treatment with prednisolone alone, [12] this is very rare, and in our patient, the Kaposi's sarcoma lesions regressed and re mained latent for 3 years while on prednisolone alone. It also regressed twice on withdrawing CyA and azathio prine, respectively, while the patient was still taking pred nisolone.…”

Section: Discussionmentioning

confidence: 48%

Does Regressed Posttransplantation Kaposi’s Sarcoma Recur following Reintroduction of Immunosuppression?

Al-Sulaiman

Mousa²,

Dhar³

et al. 1992

Am J Nephrol

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We report a patient who developed generalized Kaposi’s sarcoma (extensive skin and stomach lesions) 24 months after renal transplantation whilst on cyclosporin (CyA) and prednisolone. Kaposi’s sarcoma disappeared completely upon withdrawal of CyA. The patient remained with a well-functioning graft and free of Kaposi’s sarcoma for 36 months on prednisolone alone. CyA was reintroduced following an episode of acute rejection. Within 8 weeks, Kaposi’s sarcoma reappeared on the skin at the same sites as the previously healed lesions. They completely disappeared again upon withdrawal of CyA. Azathioprine was then introduced and Kaposi’s sarcoma lesions reappeared 6 months later.

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Section: Discussionmentioning

confidence: 48%

Does Regressed Posttransplantation Kaposi’s Sarcoma Recur following Reintroduction of Immunosuppression?

Al-Sulaiman

Mousa²,

Dhar³

et al. 1992

Am J Nephrol

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“…141 Differences in immunosuppressive therapy may favor HHV-8 reactivation in transplant recipients. [142][143][144][145][146][147][148][149][150][151] KS may develop after the use of prednisone or other immunosuppressives in settings other than of transplantation. 142,152-154 KS has been seen more often in patients whose treatment includes cyclosporine, 117,132 a drug that may reactivate HHV-8 from latency to lytic replication in tissue culture.…”

Section: Iatrogenic Ksmentioning

confidence: 99%

Kaposi sarcoma: A continuing conundrum

Schwartz

Micali

Nasca

et al. 2008

Journal of the American Academy of Dermatology

201

212

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“…In recent years, Kapos i's sarcoma has emerged as a common malignancy associated with th e acquired immu n e defic iency syndrome (AIDS) and is fo und in up to 30% of ad ul t cases (2). In addition, t here has been a number of reports of Kaposi's sarcoma associated with immunosuppression, usuall y secondary to renal transplan tation (3)(4)(5)(6), but also to the use of immunosuppress ive drugs in other <liseases (7)(8)(9). Dermacomyositis, a lthou gh assoc ia t ed wit h oth er neoplasms, h as been rare ly described in Kaposi's sarcoma.…”

mentioning

confidence: 99%

Dermatomyositis with Kaposi’s Sarcoma in a Patient without Human Immunodeficiency Virus-1 Infection

Liang

Szilagyi

Billick

et al. 1991

Canadian Journal of Gastroenterology

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myositis with Kaposi's sarcoma in a patient without human immunodeficiency virus-1 infection. Can J Gastroenterol 1991;5(1):l-4. The first case of dermatomyosit is complicating cutaneous and visceral Kaposi's sarcoma is presented in a 75-year-old man without human immunodeficiency virus infection. Dermacomyositis preceded a definitive diagnosis of Kaposi's sarcoma by six months, although in retrospect unrecognized lesions may have presented simultaneously. He was treated with prednisone and azathioprine, thus raising the possibility of the role of immunosuppression in promoting progress ion of the sarcoma. le is suggested that although the association between dermatomyosicis and Kaposi's sarcoma occurs rarely, dennatomyositis should be considered a paraneoplastic syndrome of Kaposi's sarcoma. Further, the finding of cutaneous les ions of Kaposi's sa rcoma co uld pred ict gastrointestinal involvement when dermatomyositis and Kaposi's sarcoma occur in the same patient Key Words: Dennatomyositis , Kaposi's sarcoma Dermatomyosite associee a un sarcome de Kaposi chez un patient non infecte par le virus d'immunodeficience humaine 1 RESUME: O n presence un cas de dcrmatomyosite compliquant un sa rcome de Kaposi (SK) cuta ne et visceral chez un homme de 75 ans qui n 'etait pas in fecte par le VIH. La dermatomyosite a precede le diagnostic fennel du SK de six mois, bien qu'en re trospective des lesions meconnues aie nt p u se manifest er simultanement. Le patient a ere traitc par la prednisone et l'azathioprine, ce qui evoque la possibilite du role de l'immunosuppression comme agent favorisant !'evolution du sarcome. On suggere que, bien que !'association dermatomyosite et sarcome de Kaposi soit ra re, la dennatomyosice soit consideree comme syndrome paraneoplasique d'un sa rcome de Kaposi. Plus encore, la decouverte des lesions cutanees du SK pourrait evoquer une atteinte gastrointestinale quand la dermatomyosite et le sarcome de Kaposi se declarent c hez un meme patient.

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Kaposi's sarcoma after immunosuppressive therapy with prednisone

Cited by 19 publications

References 0 publications

Does Regressed Posttransplantation Kaposi’s Sarcoma Recur following Reintroduction of Immunosuppression?

Does Regressed Posttransplantation Kaposi’s Sarcoma Recur following Reintroduction of Immunosuppression?

Kaposi sarcoma: A continuing conundrum

Dermatomyositis with Kaposi’s Sarcoma in a Patient without Human Immunodeficiency Virus-1 Infection

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Kaposi's sarcoma after immunosuppressive therapy with prednisone

Cited by 19 publications

References 0 publications

Does Regressed Posttransplantation Kaposi&rsquo;s Sarcoma Recur following Reintroduction of Immunosuppression?

Does Regressed Posttransplantation Kaposi&rsquo;s Sarcoma Recur following Reintroduction of Immunosuppression?

Kaposi sarcoma: A continuing conundrum

Dermatomyositis with Kaposi’s Sarcoma in a Patient without Human Immunodeficiency Virus-1 Infection

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Does Regressed Posttransplantation Kaposi’s Sarcoma Recur following Reintroduction of Immunosuppression?

Does Regressed Posttransplantation Kaposi’s Sarcoma Recur following Reintroduction of Immunosuppression?