Kadar 25-hydroxyvitamin D sebagai penanda sepsis pada anak

Tjowanta, Austin Simon; Yoel, Chairul; Lubis, Munar

doi:10.14238/sp19.3.2017.150-5

Cited by 2 publications

(1 citation statement)

References 20 publications

(24 reference statements)

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“…Vitamin D deficiency in neonates was correlated with neonatal sepsis incidence [15]. In several pediatrics studies, significant relationships were reported between Vitamin D deficiency and sepsis [16]. Kanth et al, (2016) reported the majority of neonates (64.1%) with neonatal sepsis were suffering from Vitamin D deficiency, and Vitamin D was statistically significant to neonatal sepsis (p = 0.05) [6].…”

Section: Discussionmentioning

confidence: 98%

The Relationship between Vitamin D Levels and Clinical Outcomes of Neonatal Sepsis in Haji Adam Malik Hospital Medan, Indonesia

Kamsiah

Hasibuan²,

Arto

2021

Open Access Maced J Med Sci

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BACKGROUND: Vitamin D deficiency in neonates is associated with neonatal sepsis incidence. It is also significantly correlated to the increased risk in the outcomes of sepsis, such as mortality, length of hospital stay, and use of ventilatory support. AIM: The aim of the study is to observe the relationship between Vitamin D levels and clinical outcomes of sepsis in the neonatal unit. METHODS: An analytical cross-sectional study was conducted to neonates in neonatology Haji Adam Malik hospital from June 2019 to February 2020. A Chi-square test was carried out to observe the relationship between Vitamin D levels and sepsis outcomes, and a Mann-Whitney test was done to assess the significance between Vitamin D levels and length of hospital stay. RESULTS: Among 41 full-term and pre-term neonates, there were 75.6% (31/41) neonates with Vitamin D deficiency, while 24.4% (10/41) had normal Vitamin D levels and did not suffer from deficiency. The relationship of Vitamin D levels with mortality, use of ventilatory support, length of stay, and blood culture was p = 0.660 (95% confidence interval [CI] = 0.810–1.677), p = 0.013 (p < 0.05), p = 0.940 (median 21 days), and p =0.712 (95% CI = 0.623–1.353), respectively. CONCLUSION: Vitamin D deficiency had a significant relationship with ventilatory support requirement as one of the sepsis outcomes in neonates.

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Section: Discussionmentioning

confidence: 98%

The Relationship between Vitamin D Levels and Clinical Outcomes of Neonatal Sepsis in Haji Adam Malik Hospital Medan, Indonesia

Kamsiah

Hasibuan²,

Arto

2021

Open Access Maced J Med Sci

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Comparison of 25-Hydroxyvitamin D Levels in Pediatric Hematologic Cancer with and without Suspected Sepsis

Lim¹,

Rejeki²,

Ugrasena³

2021

Indonesian J. Clin. Pathol. Med. Lab.

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Vitamin D is known to play an important role in fighting infections through innate and adaptive immune systems. Children with cancer have a higher risk of suffering sepsis and vitamin D deficiency. Some studies on vitamin D levels in pediatric cancer with sepsis have shown varied results and remain controversial. This study aimed to analyze 25-hydroxyvitamin D levels in pediatric hematologic cancer with and without suspected sepsis. The study was an observational analytical study with a cross-sectional design. Samples were collected during April–September 2019 from the Pediatrics Outpatient Clinic of the Dr. Soetomo Hospital, Surabaya. The samples were a group of pediatric hematologic cancer consisted of 32 subjects with suspected sepsis and 30 without sepsis. Each group was measured the 25-hydroxyvitamin D levels, then differences in levels of 25-hydroxyvitamin D between groups were assessed. Vitamin D levels were measured using ADVIA Centaur. Both groups had low 25-hydroxyvitamin D levels with a deficiency state of 96.9% and 80% in the suspected sepsis group and group without sepsis. There were differences in levels of 25-hydroxyvitamin D in pediatric cancer with and without suspected sepsis (p=0.045). Lower vitamin D levels were found in the cancer group with suspected sepsis. Low vitamin D levels reduce T-helper 2 activity, decrease cellular immunity, and decrease phagocytic macrophages, leading to an easier entry of pathogens and bacteremia. There were significant differences in 25-hydroxyvitamin D levels in pediatric hematologic cancer with and without suspected sepsis.

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Kadar 25-hydroxyvitamin D sebagai penanda sepsis pada anak

Cited by 2 publications

References 20 publications

The Relationship between Vitamin D Levels and Clinical Outcomes of Neonatal Sepsis in Haji Adam Malik Hospital Medan, Indonesia

The Relationship between Vitamin D Levels and Clinical Outcomes of Neonatal Sepsis in Haji Adam Malik Hospital Medan, Indonesia

Comparison of 25-Hydroxyvitamin D Levels in Pediatric Hematologic Cancer with and without Suspected Sepsis

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