Juvenomimetic activity of the gumoleoresin of Boswellia serrata

Dennis, T. J.; Kumar, K. Akshay; Srimannarayana, G.; Raghunathrao, D.

doi:10.1016/s0367-326x(99)00040-4

Cited by 7 publications

(6 citation statements)

References 2 publications

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“…In the course of our chemical studies of plants belonging to the family Guttiferae, we have investigated the lipophilic extract of the fruits of Kilmeyera pumila Pohl and this led to the isolation of two phenylcoumarins, (I) and (II) (see scheme). The title compound, (I), named mammeigin [or mammea A/AA cycle D, or 5-hydroxy-8,8-dimethyl-6-(3-methylbutanoyl)-4-phenyl-2H,8H-pyrano[2,3-f]chromen-2-one (9CI)], has already been isolated from Guttiferae species (Lopez-Perez et al, 2005;Reutrakul et al, 2003;Gramacho et al, 1999;Dennis & Akshaya Kumar, 1998;Castellano et al, 1988;Crombie et al, 1987Crombie et al, , 1967Carpenter et al, 1971;Chakraborty & Chatterji, 1969;Finnegan & Mueller, 1964), and its structure has been established based on spectroscopic evidence and chemical correlation (Finnegan & Mueller, 1965). The structure of (II), a phenylcoumarin from Guttiferae species, was proposed for a new natural product named isomammeigin from IR and NMR data (de Abreu e Silva, 1987).…”

Section: Commentmentioning

confidence: 99%

Mammeigin

Ellena¹,

Santos

Moreira

et al. 2006

Acta Crystallogr C

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Single crystals of the phenylcoumarin named mammeigin (or mammea A/AA cycle D) [systematic name: 5-hydroxy-8,8-dimethyl-6-(3-methylbutanoyl)-4-phenyl-2H,8H-pyrano[2,3-f]chromen-2-one], C25H24O5, were obtained in the course of a chemotaxonomic study of the Guttiferae family. Mammeigin was extracted from the fruits of Kilmeyera pumila. The structure reveals an infinite three-dimensional network stabilized by non-classical intermolecular hydrogen bonds.

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Section: Commentmentioning

confidence: 99%

Mammeigin

Ellena¹,

Santos

Moreira

et al. 2006

Acta Crystallogr C

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“… SL. No Compound name Reference PubMed ID Molecular Formula E value 1 α Boswellic acid 60 637234 C 30 H 48 O 3 − 282.35 2 Cadinene 61 441005 C 15 H 24 − 192.87 3 p-Cymene 61 7463 C 10 H 14 − 186.78 4 Elemolic acid 56 , 57 441677 C 30 H 48 O 3 − 309.23 5 Limonene 62 22311 C 10 H 16 − 258.91 6 Lupeolic acid 54 , 63 12111950 C 30 H 48 O 3 − 280.46 7 Phellendrene 64 7460 C 10 H 16 − 197.25 8 Serratol 56 101618281 …”

Section: Resultsmentioning

confidence: 99%

Group IIA secreted phospholipase A2 inhibition by elemolic acid as a function of anti-inflammatory activity

Krishnappa

Urs

Manjunatha

et al. 2022

Sci Rep

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Human group IIA secreted phospholipase A2 (GIIA) is a key enzyme in inflammatory reactions, worsening the condition of several chronic inflammatory diseases. The natural inhibitors of GIIA potentially block the production of inflammatory mediators. In the present study, elemolic acid, a triterpenoid from Boswellia serrata inhibited the GIIA enzyme in a concentration-dependent manner with IC50 value of 5.70 ± 0.02 µM. The mode of GIIA inhibition was studied by increasing the concentration of the substrate from 30 to 120 nM, and calcium from 2.5 to 15 mM, the level of inhibition was not changed. The inhibitor-enzyme interaction was examined by fluorimetry and Circular Dichroism (CD) studies; elemolic acid altered intrinsic fluorescence intensity and shifted far UV- CD spectra of GIIA enzyme, suggesting the direct interaction with GIIA. Elemolic acid neutralized the GIIA mediated indirect hemolytic activity from 94.5 to 9.8% and reduced GIIA induced mouse paw edema from 171.75 to 113.68%. Elemolic acid also reduced the hemorrhagic effect of GIIA along with Vipera russelii neurotoxic non-enzymatic peptide -VNTx-II (VR-HC-I). Thus, the elemolic acid has been proven as a potent inhibitor of GIIA enzyme and modulated the GIIA induced inflammatory response by in situ and in vivo methods.

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“…10 The essential oil and absolute from the oleo-gum-resin of B. serrata are used as fixatives in perfumes, soaps, creams, lotions and detergents 11 and are found to be effective on male gonads of Dysdercus similes 12 and show juvenomimetic activity. 13 GC examination of the essential oils studied revealed the presence of α-thujene in the gum resin oil 14 and α-pinene as the prime constituent in the bark oil, 15 along with small amounts of carene-3, limonene, pcymene, linalool and geraniol.…”

Section: Introductionmentioning

confidence: 99%

Volatile constituents of natural Boswellia serrata oleo‐gum‐resin and commercial samples

Singh

Kumar

Bhandari

et al. 2006

Flavour & Fragrance J

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The essential oils of Boswellia serrata Roxb. ex Colebr. oleo-gum-resin collected from four different locations (samples A-D) were isolated by hydrodistillation and analysed by means of GC and GC-MS. Thirty-five components were identified, comprising 82%, 91%, 77% and 82% of samples A, B, C and D, respectively. α α α α α -Thujene was one of the major constituents in all samples, whereas α α α α α -pinene was recorded in only one sample. All the oils were dominated by monoterpene hydrocarbons.

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Juvenomimetic activity of the gumoleoresin of Boswellia serrata

Cited by 7 publications

References 2 publications

Mammeigin

Mammeigin

Group IIA secreted phospholipase A2 inhibition by elemolic acid as a function of anti-inflammatory activity

Volatile constituents of natural Boswellia serrata oleo‐gum‐resin and commercial samples

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