Juvenile xanthogranuloma of skull base. Case report and review of the literature

Puerta, Patricia; Candela, Santiago; Rovira, Carlota; Fructuoso, G. García

doi:10.1007/s00701-013-1718-9

Cited by 5 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 Extracutaneous HN JXG has been reported in locations such as the tympanic membrane, nasal cavity, tongue, orbit and paranasal sinus, subglottis, cervical spine, skull base including the temporal bone, intracranial compartment, and HN muscles. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Cutaneous JXG typically presents as a solitary macule or papule with a flesh-colored, erythematous, or yellowish hue. 2 In such cases, radiographic imaging is not indicated.…”

mentioning

confidence: 99%

Imaging Features of Juvenile Xanthogranuloma of the Pediatric Head and Neck

Ginat

Vargas

Silvera

et al. 2016

American Journal of Neuroradiology

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Imaging Features of Juvenile Xanthogranuloma of the Pediatric Head and Neck

Ginat

Vargas

Silvera

et al. 2016

American Journal of Neuroradiology

View full text Add to dashboard Cite

show abstract

“…Total resection usually has a favourable outcome. As shown in Table 1 , both patients who underwent total surgical removal had no evidence of the disease during 19–36 months of follow-up [ 3 ]. In contrast, two of the three patients with partial resection were in stable condition during 6–21 months of follow-up [ 4 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Skeletal JXG manifestations of systemic cases have also been reported, but isolated bone lesions are rare. We searched PubMed Central to identify peer-reviewed studies of skull JXG and found reports of only 4 cases of isolated skull JXG since 1997 [ 1 , 3 – 5 ]. Clinical symptoms of isolated skull JXG vary depending on the location of the mass.…”

Section: Introductionmentioning

confidence: 99%

Solitary juvenile xanthogranuloma of temporal bone: a case report

Wang

2022

BMC Pediatr

View full text Add to dashboard Cite

Background Juvenile xanthogranuloma (JXG) is a kind of non-Langerhans cell histiocytosis, usually with skin lesions as the main manifestation. It rarely occurs in other tissues or organs and even more rarely is it found in the skull. Here, we report a case of xanthogranuloma derived from the temporal bone that was not present in any other parts of the body. Case presentation A 15-year-old boy had an unaccountable right migraine for 7 months. A mass with tenderness was located behind his right ear. The mass gradually increased in size, and his headache continued. Eventually, he came to our hospital for treatment. A computed tomography (CT) scan and magnetic resonance imaging (MRI) revealed a cystic solid mass in the right temporo-occipital region with skull destruction. The clinical diagnosis was haemangiopericytoma and skull-derived tumour. Haematological and biochemical results were as follows: alanine aminotransferase (ALT) 7 U/L; aspartate aminotransferase (AST) 12 U/L; basophil percentage (BASO%) 1.2%; normal coagulation. The patient was successfully treated with total surgical resection of the tumour. Postoperative histopathology examination showed xanthogranuloma, and his prognosis after surgery was good. Conclusions Because JXG rarely occurs in the skull and lacks typical imaging findings, an accurate diagnosis is difficult. The diagnosis of this disease mainly depends on pathological examination and immunohistochemistry. If feasible, many intracranial lesions can be cured through complete resection.

show abstract

“…Spontaneous regression has only been reported in the case of one oral lesion.2 If the lesion does not regress, treatment usually consists of surgical excision [2]. If surgery is not feasible, radiation therapy or chemotherapy have been used [12][13][14][15][16][17][18][19][20]. Although rare, systemic xanthogranuloma is associated with significant morbidity and occasional deaths.11 If possible, surgical excision is usually curative for systemic xanthogranuloma as well [20].…”

Section: Discussionmentioning

confidence: 99%

“…Electron microscopy demonstrating Birbeck Granules would confirm the presence of Langerhans cells, further solidifying the diagnosis of Langerhans cell histiocytosis [8]. While the appearance of the class I and class II histiocytic disorders may be very similar, the prognosis is worse for Langerhans cell histiocytosis [14]. Because histology and immunohistochemical findings were not consistent with this diagnosis, Langerhans cell histiocytosis was ruled out of the final diagnosis.…”

Section: Differential Diagnosismentioning

confidence: 92%

A Nonhealing Periapical Radiolucency

Vargo

Bilodeau

Jaradat

et al. 2016

JDHODT

View full text Add to dashboard Cite

Background: This case discusses a radiolucent lesion in the anterior mandible, which initially was thought to be due to endodontic failure. However, the final diagnosis was xanthogranuloma. Case description:We have reported a case of xanthogranuloma in the mandible found at the apices of two endodontically treated teeth. When present in the oral cavity, it can appear similar to several more common entities. While the radiolucent periapical lesion was thought to be the result of non-healing root canal therapy, the excisional biopsy yielded the diagnosis of xanthogranuloma. Removal of the lesion has resulted in excellent healing, as the surgeon expected. Practical implications:This case demonstrates the importance of biopsy in definitive diagnosis of oral lesions and lesions found at the apices of previously endodontically treated teeth.

show abstract

Juvenile xanthogranuloma of skull base. Case report and review of the literature

Cited by 5 publications

References 13 publications

Imaging Features of Juvenile Xanthogranuloma of the Pediatric Head and Neck

Imaging Features of Juvenile Xanthogranuloma of the Pediatric Head and Neck

Solitary juvenile xanthogranuloma of temporal bone: a case report

A Nonhealing Periapical Radiolucency

Contact Info

Product

Resources

About