Juvenile xanthogranuloma and urticaria pigmentosa

Villez, Richard L. De

doi:10.1001/archderm.111.3.365

Cited by 20 publications

(10 citation statements)

References 15 publications

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“…However, literature data support our results. The gastric pH for some crustacean species were reported to range between pH 5.3 and 6.2 [5,22], the maximum activity of total proteinase appeared in a broad range between pH 5 and 8 [21,[23][24][25] and the maximum of trypsin activity was found at pH 7-8.2 [21,24]. However, also the maximum activity of chymotrypsin ranged between pH 5 and 8 [26].…”

Section: Ph-profilesmentioning

confidence: 99%

Stability and effects of organic solvents on endopeptidases from the gastric fluid of the marine crab Cancer pagurus

Saborowski

Sahling

Toro³

et al. 2004

Journal of Molecular Catalysis B: Enzymatic

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Activities of proteolytic enzymes, represented by azocasein digestion (total protease), trypsin, and chymotrypsin from the gastric fluid of the marine crab, Cancer pagurus, were evaluated for operational parameters like pH-optimum, thermal stability, and effectors such as metal ions and organic solvents. Total protease activity was 98.5 ± 4.3 E 366 min −1 ml −1 . Trypsin and chymotrypsin activities amounted to 14.7 ± 1.5 U ml −1 and 197 ± 59 U ml −1 , respectively. The maximum activity of total protease appeared at pH 5-7, that of trypsin at pH 7-9, and that of chymotrypsin at pH 6.5-7. Trypsin and chymotrypsin activities were slightly activated by Ca 2+ , but were drastically reduced by Zn 2+ . In the presence of 2-propanol, trypsin activity was enhanced 8-fold at 30• C. Highest amplification of activity of up to 30-fold, however, appeared below 12• C. The effects of ethanol and acetone were less distinct. These caused a 2.5-fold increase of activity. Methanol was the least activating solvent.Activities of all enzymes remained stable for up to 127 days at 5• C, keeping up to 70% of the initial activity. When stored at 25• C for 120 days, total protease decreased to about 40% and trypsin and chymotrypsin activities kept more than 60% of initial activity. Zymograms showed five major and several minor proteolytic bands with apparent molecular weight of 20-45 kDa. After long-term storage at room temperature, the major bands remained active, while some bands with minor activity disappeared. This proteolytic enzyme preparation from the gastric fluid of crab seems suitable for biotechnological application at neutral pH and in the presence of organic solvents.

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Section: Ph-profilesmentioning

confidence: 99%

Stability and effects of organic solvents on endopeptidases from the gastric fluid of the marine crab Cancer pagurus

Saborowski

Sahling

Toro³

et al. 2004

Journal of Molecular Catalysis B: Enzymatic

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“…24 The natural course of typical JXGs is spontaneous regression of lesions, usually occurring by 12 months of age. 13 Giant JXGs are also reported to involute spontaneously; therefore, excision is only indicated for those lesions that cause functional impairment, or have secondary complications such as infection or bleeding, or when diagnostic uncertainty exists. Atrophic areas or macules with altered pigmentation may persist after regression of cutaneous JXG.…”

Section: Discussionmentioning

confidence: 99%

Disseminated juvenile xanthogranulomatosis in a newborn resulting in liver transplantation

Haughton¹,

Horii

Shao

et al. 2008

Journal of the American Academy of Dermatology

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“…Ainsi, on a décrit des neu rofibromatoses survenant chez des individus porteurs de naevi pigmentés multiples, de cutis laxa ou de xanthogranulomes juvéniles [7], D'un autre côté, la mastocytose a été dé crite chez des individus psoriasiques 15], ou ayant des xanthogranulomes [5], une scléro dermie [I ] ou un vitiligo [14], Mais il semble en réalité que toutes ces associations soient fortuites.…”

Section: Discussionunclassified

Neurofibromatose de Von Recklinghausen et mastocytose systémique

Mérot¹,

Bauquis²,

Saurat³

1984

Dermatology

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We describe a 62-year-old woman who presented with a recurrent neurofibroma, two ‘café-au-lait’ spots and a possible cerebral tumor. This Von Recklinghausen neurofibromatosis was associated with an asymptomatic systemic mastocytosis with bone marrow involvement. We discuss Riccardi’s recent theory on the pathogenesis of neurofibroma which postulates that the mast cells have a primordial role in the development of neurofibroma. Our observation could be additional evidence in favor of this theory.

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Juvenile xanthogranuloma and urticaria pigmentosa

Cited by 20 publications

References 15 publications

Stability and effects of organic solvents on endopeptidases from the gastric fluid of the marine crab Cancer pagurus

Stability and effects of organic solvents on endopeptidases from the gastric fluid of the marine crab Cancer pagurus

Disseminated juvenile xanthogranulomatosis in a newborn resulting in liver transplantation

Neurofibromatose de Von Recklinghausen et mastocytose systémique

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