“…[ 2 ] In pediatric systemic sclerosis, they are found at a similar prevalence of about 7%. [ 3 ] They tend to identify younger scleroderma patients (37 vs. 43-year-old at disease onset),4 and are associated with poorer survival compared to AFA-negative systemic sclerosis. [ 5 ] Patients with AFA tend to have more extensive skin, muscle, pulmonary, and cardiac complications of systemic sclerosis.…”