Juvenile linear scleroderma associated with serologic abnormalities

Coexistent Linear Scleroderma and Juvenile Systemic Lupus Erythematosus

“…Antinuclear antibodies, mainly in a homogeneous pattern, and RF have been detected in the serum of 67% and 41%, respectively, of patients with linear scleroderma (11,12). Up to 50% of linear scleroderma patients have antibodies to ssDNA (13).…”

“…Although the pathogenic significance of these antibodies in patients with linear scleroderma is unclear, it suggests that immunologic mechanisms may play a role in the pathogenesis. It should also alert the physician to evaluate for other possible collagen vascular diseases or a usual overlap syn- drome (12,13). The course of the scleroderma and clinical and laboratory findings consistent with SLE in our patient are indicative of coexistence rather than overlap between the two diseases.…”

Pediyatrik Morfea (Lokalize Skleroderma) 14 Olguya Ait Epidemiyolojik Klinik ve Laboratuvar Bulguları

“…19 ANA ve RF pozitifliğinin ekstrakutanöz tutulum açısından uyarıcı olması gerektiğine dikkat çekmiştir. Hasta grubumuzda inflamasyon parametrelerinde artış saptanmadı.…”