Juvenile Human T Lymphotropic Virus Type 1–Associated Myelopathy

Araujo, Anna Carla; Fontenelle, L.; Pádua, Paula A. B.; Filho, Heber S. Maia; Araújo, Abelardo de Queiroz Campos

doi:10.1086/341251

Cited by 36 publications

(53 citation statements)

References 23 publications

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“…Back pain is mostly considered as inflammatory nociceptive type; however, roots compression is frequent- 10,25 , and even in juvenile cases 32 . Neuropathic pain is mainly expressed in the form of paresthesias, leg pain, burning and shooting pain.…”

Section: Resultsmentioning

confidence: 99%

Pain in tropical spastic paraparesis/HTLV-I associated myelopathy patients

Castro-Costa

Araújo

Câmara

et al. 2009

Arq. Neuro-Psiquiatr.

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-Objective: Tropical Spastic Paraparesis/HTLV-I Associated Myelopathy (TSP/HAM) is a chronic myelopathy, and pain has been mentioned as a frequent sensory symptom in this condition. The authors aimed at analyzing this symptom in a TSP/HAM patients series. Method: For this, 46 patients were analyzed considering demographic and clinical characteristics and complaint of pain as to verbal description, time of onset and classification, correlated with the degree of motor disability and type of pain. Results: Among the 46 TSP/HAM patients, 28 (60.8%) complained of pain, predominant in the early phase of the disease. Most of the patients exhibited neuropathic characteristics of pain, correlated with increased motor disability. Conclusion: Pain in TSP/HAM patients is a frequent and early symptom, and the neuropathic type is predominant (57.1%) and paralleled with increased incapacitation. The pathogenic involvement of cytokines may possibly be involved in the meaning of this symptom in this condition.Key wordS: TSP/HAM, HTLV-I, pain, inflammatory nociceptive and neuropathic, cytokines.dor em pacientes com paraparesia espástica tropical/mielopatia associada ao HTlV-i resumo -Objetivo: A Paraparesia espástica Tropical/Mielopatia Associada ao HTLV-I (PeT/MAH) é uma mielopatia crônica, e a dor tem sido mencionada como um sintoma sensitivo freqüente nessa condição. os autores objetivam analisar esse sintoma numa série de pacientes com PeT/MAH. Método: Para isso, 46 pacientes foram analisados considerando características demográficas e clínicas, e queixa de dor do ponto de vista da descrição verbal, tempo de início e classificação, correlacionados com o grau de incapacitação motora e o tipo de dor. Resultados: dentre os 46 pacientes com PeT/MAH, 28 (60,8%) se queixavam de dor, predominando na fase inicial da doença. A maioria dos pacientes evidenciou características de dor neuropática, correlacionada com aumento da incapacitação motora. Conclusão: A dor em pacientes com PeT/MAH é um sintoma freqüente e inicial, sendo o tipo neuropático predominante (57,1%) e em paralelo com maior incapacitação. o envolvimento patogênico das citocinas poderá possivelmente estar relacionado com o significado desse sintoma nessa condição clínica.PALAVrAS-CHAVe: PeT/MAH, HTLV-I, dor, nociceptiva inflamatória e neuropática, citocinas.

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Section: Resultsmentioning

confidence: 99%

Pain in tropical spastic paraparesis/HTLV-I associated myelopathy patients

Castro-Costa

Araújo

Câmara

et al. 2009

Arq. Neuro-Psiquiatr.

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“…Embora a HAM/TSP seja considerada patologia do adulto, há, na literatura, 17 relatos bem documentados de HAM/ TSP diagnosticados na faixa etária infanto-juvenil, dos quais 13 foram descritos no Brasil 47,49,[55][56][57][58][59][60][61] . Nesses casos, houve também predomínio do sexo feminino.…”

Section: Forma Infanto-juvenil Da Ham/tspunclassified

“…A forma infanto-juvenil da HAM/TSP, embora apresente manifestações clínicas semelhantes às do adulto, é diferente quanto à evolução, que é rapidamente progressiva 47,58 .…”

Section: Quadro Clínico Diagnóstico E Evoluçãounclassified

“…De acordo com os estudos, a melhora clínica acompanha-se, em alguns pacientes, da diminuição do título de anticorpos e da celularidade no LCR. A pulsoterapia com metilprednisolona durante 3-5 dias, seguida de prednisona oral (1 mg/kg/dia) por tempo indeterminado, é indicada nos casos de evolução aguda ou subaguda associada à rápida deterioração funcional e ao padrão inflamatório do liquor 47,58 . Outras alternativas terapêuticas, como alfainterferon, gamaglobulina, vitamina C, pentoxifilina e danazol, vêm sendo utilizadas 63 .…”

Section: Tratamentounclassified

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Manifestations of the human T-cell lymphotropic virus type I infection in childhood and adolescence

Bittencourt¹,

Primo²,

Oliveira³

2006

J Pediatr (Rio J)

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Objectives: To review the literature on diseases linked with infection by human T-cell lymphotropic virus type I (HTLV-I) in childhood and adolescence, with focus on clinical aspects, diagnosis, pathogenesis, progression and treatment.Sources: Medical literature published during the last 20 years identified using PubMed and MEDLINE and from specialized medical books, with emphasis on infective dermatitis associated with HTLV-I (IDH), on the juvenile form of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP), on adult T-cell leukemia/lymphoma (ATL) and on HTLV-I-associated uveitis. Keywords used to search databases were: HTLV-I-associated infective dermatitis, HTLV-Iassociated myelopathy/tropical spastic paraparesis, adult T-cell leukemia/lymphoma, HTLV-I-associated uveitis.Summary of the findings: IDH is a chronic, relapsing and infected dermatitis of childhood which always involves the scalp and which may progress to HAM/TSP and ATL. HAM/TSP is a chronic and incapacitating myelopathy of adults. There are 17 well-documented cases of HAM/TSP in children and adolescents in the literature, 12 of whom are patients with IDH. In contrast with the adult form of the disease, the juvenile form is rapid and progressive. ATL is a type of T-cell leukemia/ lymphoma that affects adults and is generally fatal. Eleven of the 24 published reports of ATL in children and adolescents were diagnosed in Brazil.Conclusions: These diseases are likely to be more common in childhood and adolescence than the literature would suggest. It is advisable that serological testing be performed for HTLV-I in children and adolescents suffering from chronic and relapsing eczema, with signs and symptoms of myelopathy or with a diagnosis of T-cell leukemia/lymphoma. It is important that pediatricians know how to recognize the pediatric manifestations of this infection in order to correctly diagnose them and offer their patients appropriate guidance and treatment.

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“…42 On the other hand, the Pityrosporum yeasts, which frequently occur in SD, 43 Although HAM/TSP is considered a pathology of adults, there are 17 well-documented cases in the literature of HAM/TSP diagnosed in children and adolescents, 13 of which were described in Brazil. 47,49,[55][56][57][58][59][60][61] In these cases a predominance of the female sex was observed. In contrast with the adult form of the disease, in the juvenile form of HAM/TSP infection is acquired vertically.…”

Section: Differential Clinical Diagnosismentioning

confidence: 99%

Manifestações infanto-juvenis da infecção pelo vírus linfotrópico de células T humanas (HTLV-I)

Bittencourt¹,

Primo²,

Oliveira³

2006

J. Pediatr. (Rio J.)

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Objectives: To review the literature on diseases linked with infection by human T-cell lymphotropic virus type I (HTLV-I) in childhood and adolescence, with focus on clinical aspects, diagnosis, pathogenesis, progression and treatment.Sources: Medical literature published during the last 20 years identified using PubMed and MEDLINE and from specialized medical books, with emphasis on infective dermatitis associated with HTLV-I (IDH), on the juvenile form of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP), on adult T-cell leukemia/lymphoma (ATL) and on HTLV-I-associated uveitis. Keywords used to search databases were: HTLV-I-associated infective dermatitis, HTLV-Iassociated myelopathy/tropical spastic paraparesis, adult T-cell leukemia/lymphoma, HTLV-I-associated uveitis.Summary of the findings: IDH is a chronic, relapsing and infected dermatitis of childhood which always involves the scalp and which may progress to HAM/TSP and ATL. HAM/TSP is a chronic and incapacitating myelopathy of adults. There are 17 well-documented cases of HAM/TSP in children and adolescents in the literature, 12 of whom are patients with IDH. In contrast with the adult form of the disease, the juvenile form is rapid and progressive. ATL is a type of Tcell leukemia/lymphoma that affects adults and is generally fatal. Eleven of the 24 published reports of ATL in children and adolescents were diagnosed in Brazil.Conclusions: These diseases are likely to be more common in childhood and adolescence than the literature would suggest. It is advisable that serological testing be performed for HTLV-I in children and adolescents suffering from chronic and relapsing eczema, with signs and symptoms of myelopathy or with a diagnosis of T-cell leukemia/lymphoma. It is important that pediatricians know how to recognize the pediatric manifestations of this infection in order to correctly diagnose them and offer their patients appropriate guidance and treatment.

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Juvenile Human T Lymphotropic Virus Type 1–Associated Myelopathy

Cited by 36 publications

References 23 publications

Pain in tropical spastic paraparesis/HTLV-I associated myelopathy patients

Pain in tropical spastic paraparesis/HTLV-I associated myelopathy patients

Manifestations of the human T-cell lymphotropic virus type I infection in childhood and adolescence

Manifestações infanto-juvenis da infecção pelo vírus linfotrópico de células T humanas (HTLV-I)

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