Juvenile generalized pustular psoriasis. A report of five cases and a review of the literature

Khan, S. A.

doi:10.1001/archderm.105.1.67

Cited by 24 publications

(25 citation statements)

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“…Von Zumbusch observed a male patient, who had had classic psoriasis for several years and finally developed multiple pustules [17,18]. Andrews at the Annual Session of the American Medical Association in Milwaukee 1933 presented patients with pustular eruptions of the palms and soles and described fifteen cases [19], which had clinical features similar to the description of pustular psoriasis of the extremities, given by Barber [20].…”

Section: Variants Diagnostic Signs and Histopathology Of Psoriasismentioning

confidence: 87%

Lepra vulgaris. History of Psoriasis

Burg¹,

Geiges²

2014

J Turk Acad Dermatol

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Background: The history of psoriasis, remains highly speculative for the time before Willan (1757Willan ( -1812, and can be reliably assigned only for the last 200 years. Terms such as "Leprosy", "Impetigo" and "Psora" have been used in the centuries before. Hebra (1806-1880) gave a morphological and nosologic definition, in which also the histopathology appearance was taken into account. In the early 20th century, it was the biochemistry and histochemistry, which provided new insights. In the second half of the 20th century, immunocytochemistry and immunology shed some light on the pathogenetic processes of the disease. At the end of the 20th and at the beginning of the 21st century, it is the triumph of genetics and immunology, which have opened new therapeutic possibilities due to the interesting insights into the pathogenesis of psoriasis. However besides the new therapeutic modalities, which harbor some health and some economic threats, classical approaches still remain valuable tools. AbstractBackground: The history of psoriasis, remains highly speculative for the time before Willan (1757-1812), and can be reliably assigned only for the last 200 years. Terms such as "Leprosy", "Impetigo" and "Psora" have been used in the centuries before. Hebra (1806-1880) gave a morphological and nosologic definition, in which also the histopathology appearance was taken into account. In the early 20th century, it was the biochemistry and histochemistry, which provided new insights. In the second half of the 20th century, immunocytochemistry and immunology shed some light on the pathogenetic processes of the disease. At the end of the 20th and at the beginning of the 21st century, it is the triumph of genetics and immunology, which have opened new therapeutic possibilities due to the interesting insights into the pathogenesis of psoriasis. However besides the new therapeutic modalities, which harbor some health and some economic threats, classical approaches still remain valuable tools.

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Section: Variants Diagnostic Signs and Histopathology Of Psoriasismentioning

confidence: 87%

Lepra vulgaris. History of Psoriasis

Burg¹,

Geiges²

2014

J Turk Acad Dermatol

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“…The pustules tended to flow forming an area of pus on erythematous basis 1 . The patient also presented fever and adynamia.…”

Section: Case Reportmentioning

confidence: 99%

“…1 Baker and Ryan 2 classified this type of psoriasis in four forms: von zumbusch, annular, exanthematous and localized (except for acral and palmoplantar). None of these types are mutually exclusive.…”

Section: Introductionmentioning

confidence: 99%

“…None of these types are mutually exclusive. This generalized form of psoriasis is characterized by the development of subcorneal sterile pustules superimposed on erythematous basis 1 .There are less than 200 cases of the von zumbusch form ,in children 3 , described in medical literature. The report of this case is due not only to its rarity but also to its therapeutic challenge.…”

Section: Introductionmentioning

confidence: 99%

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Psoríase pustulosa da infância: relato de caso

Chaves

Cardoso

Jorge

et al. 2010

An. Bras. Dermatol.

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Abstract:Generalized pustulous psoriasis is a rare type of psoriasis first described in 1910 by Von Zumbusch. This disease tends to have a more benign development in children when compared to its development in adults. However, in its serious form it may represent a risk to the patient's life. Maybe, due to being such a rare disease no therapeutic option has so far consistently proved to be both effective and safe. Isolated reports suggest that retinoid is the best choice of drug in these cases. However, it is difficult to manage this drug in early infancy. The present report describes a serious case of this rare disease in an infant with a satisfactory response and good tolerance to the use of dapsone. Keywords: Child; Dapsone; Psoriasis; Therapeutics Resumo: A psoríase pustulosa generalizada é tipo raro de psoríase descrita pela primeira vez, em 1910, por Von Zumbusch. A psoríase pustulosa generalizada na criança tende a ter um curso mais benigno que no adulto, entretanto, em sua forma grave, pode por em risco a vida do paciente. Talvez, pela raridade da doença, nenhuma opção terapêutica se mostrou consistentemente eficaz e segura até o momento. Relatos isolados sugerem ser o retinoide a droga de escolha nesses casos, porém trata-se de fármaco que, na primeira infância, traz mais dificuldades no manejo. Relata-se exemplo dessa rara doença em lactente, quadro extenso e grave, com resposta satisfatória ao uso de dapsona, com boa tolerabilidade.

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“…The course of the disease in children is unpredictable but usually benign. Kahn et al [4] therefore advised avoiding major therapies (methotrexate and systemic corticosteroids) until it is proven that local therapy alone cannot control the condition.…”

mentioning

confidence: 99%