Jumping translocation at 11q23 withMLL gene rearrangement and interstitial telomeric sequences

Jumping translocation in acute leukemia of myelomonocytic lineage: a case report and review of the literature

“…Jumping translocations may occur in multiple myeloma, 6 non-Hodgkin's lymphoma, 7 and acute de novo or secondary leukemia. 7,8 To our knowledge, only 13 cases of AML associated with JT have been described: one case of AML0, 7 one case of AML2, 8 two cases of APL, 9,10 seven cases of AML4/5, 8,[11][12][13][14][15][16] and one case of AML7. 17 One other unclassified AML case following juvenile chronic myelomonocytic leukemia has been reported.…”

MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study

“…We note that three cases have been reported of AML with amplification of the 11q23-qter region based on comparative genomic hybridisation (CGH) and Southern blotting studies. [30][31][32][33] In two of these three cases the MLL gene was not involved, whereas other genes from 11q23 were amplified (eg ETS1). It is possible that MLL is merely a linked passenger to another -perhaps more biologically significant -gene in some or all of these amplification events.…”

Telomeres and telomerase in hematologic neoplasia

“…Of note is that there are increasing numbers of reports dealing with interstitial telomere repeats in translocations of acute leukemias (Hatakeyama et al, 1999; Cuthbert et al, 1999;Busson Le Coniat et al, 2000). Although the genesis and the functional consequences are still unknown, further characterization of the biological role including jumping translocations would be necessary in elucidating the signi®cance of interstitial telomere repeats in acute leukemias.…”