Biochemical Pharmacology volume 80, issue 11, P1641-1649 2010 DOI: 10.1016/j.bcp.2010.08.011 View full text
Niharika Nath, Mitali Chattopadhyay, Liliya Pospishil, Lucyna Z. Cieciura, Satindra Goswami, Ravinder Kodela, Joseph E. Saavedra, Larry K. Keefer, Khosrow Kashfi

Abstract: β-Catenin is a central player of the Wnt signaling pathway that regulates cell-cell adhesion and may promote leukemia cell proliferation. We examined whether JS-K, an NO-donating prodrug, modulates the Wnt/β-catenin/TCF-4 signaling pathway in Jurkat T-Acute Lymphoblastic Leukemia cells. JS-K inhibited Jurkat T cell growth in a concentration and time-dependent manner. The IC(50)s for cell growth inhibition were 14±0.7 and 9±1.2μM at 24 and 48h, respectively. Treatment of the cells with JS-K for 24h, caused a do…

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