Joint-action ecotoxicity of binary mixtures of glutaraldehyde and surfactants used in hospitals: Use of the Toxicity Index model and isoblogram representation

Boillot, Clotilde; Perrodin, Yves

doi:10.1016/j.ecoenv.2007.08.010

Cited by 49 publications

(28 citation statements)

References 31 publications

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“…However, this approach has some potential side effects, such as the formation of carcinogens and trihalomethanes [11]. Researchers hope that combinations of chemicals or physical agents may have physical or chemical synergistic effects, such that the toxicity and amount of residual disinfectant can be reduced [12,13]. Gilbert [14] reported that the effect of quaternary ammonium compounds on Pseudomonadaceae could be improved by combining them with a chelating agent such as EDTA.…”

Section: Quantitation Of Intracellular Atpmentioning

confidence: 99%

Bactericidal Activity and Physiological Effects of Combined Application of Poly-Hexamethylene Biguanide Hydrochloride and 1-bromo-3-chloro-5, 5-dimethylimidazolidine-2, 4-dione on Staphylococcus aureus

Huai¹,

Deng²,

Chen³

2017

Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)

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Abstract-Poly-hexamethylene biguanide hydrochloride (PHMB) and 1-bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione (BCDMH) are widely used for surface disinfection. Here, we examined the bactericidal effects of the mixture of PHMB and BCDMH (named PB) combined in different ratios on S. aureus, and studied effects of temperature, pH and bovine serum albumin (BSA , as organic interferent) on PB bactericidal activity with suspension quantitative germicidal method. We also observed surface structure changes and ATP level in S. aureus treated with PB with scanning electron microscope and multi-function microplate reader, respectively. The results showed that mixture of 10 mg/L PHMB and 10 mg/L BCDMH could meet the bactericidal requirements according to Technical Standard for Disinfection (China 2002), producing similar bactericidal activity to those exhibited by 320 mg/L PHMB and 60 mg/L BCDMH, separately. The results showed that PB was competent to kill bacteria quickly and bactericidal activity increased with time within 12 min. Temperature had no significant effect on PB bactericidal activity. PB offered satisfied bactericidal activity within 3.0 to 5.0 pH range. BSA significantly reduced bactericidal activity of PB. In addition, PB treatment could result in protuberance on S. aureus surface, and bring about a rapid decline in intracellular ATP level.

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Section: Quantitation Of Intracellular Atpmentioning

confidence: 99%

Bactericidal Activity and Physiological Effects of Combined Application of Poly-Hexamethylene Biguanide Hydrochloride and 1-bromo-3-chloro-5, 5-dimethylimidazolidine-2, 4-dione on Staphylococcus aureus

Huai¹,

Deng²,

Chen³

2017

Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)

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“…It was indicated that the GA had clearly acute toxicity to aquatic organisms (Leung 2001). For example, the acute EC50 values of GA to Raphidocelis subcapitata (Chen et al 2005), Daphnia magna (Boillot and Perrodin 2008), and Pseudokirchneriella subcapitata (Sano et al 2005) are 13.20, 20.03, and 1.0 mg/L, respectively.…”

mentioning

confidence: 98%

“…Previous studies were done in this aspect. For example, Boillot determined the combined effects of GA and three surfactants on D. magna (Boillot and Perrodin 2008). The combined effects of GA and surfactant mixtures on aquatic organisms were also experimentally determined by Emmanuel et al (2005).…”

mentioning

confidence: 99%

A new effect residual ratio (ERR) method for the validation of the concentration addition and independent action models

Wang

Liu

Zhang

et al. 2009

Environ Sci Pollut Res

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“…TI = 1 describes additivity, TI > 1 describes antagonistic interaction and TI < 1 describes synergistic interaction (Boillot & Perrodin, 2008).…”

Section: The Toxic Unit (Tu) and Toxic Index (Ti)mentioning

confidence: 99%

Toxicity of Quaternary Mixtures of Phenolic Compounds and Formulated Glyphosate to Microbial Community of River Water

Nweke

Ike

Ibegbulem

2024

Ecotoxicol. Environ. Contam.

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The toxicity of mixtures of formulated glyphosate, phenol, 4-chlorophenol and 2,4-dichlorophenol to river water microbial community was investigated using non specific dehydrogenase activity as endpoint. The microbial community was exposed to individual toxicant and quaternary mixture ratios at concentrations ranging from 50 mg L -1 to 3000 mg L -1 over 24 h. The ecological doses (EC 50 ) as estimated from logistic or hormesis dose-effect models were 1317.946 ± 51.460 mg L -1 , 1046.414 ± 65.534 mg L -1 , 85.080 ± 4.468 mg L -1 and 60.897 ± 5.199 mg L -1 for formulated glyphosate, phenol, 4-chlorophenol and 2,4-dichlorophenol respectively. The toxicity and interaction of the mixtures were evaluated using concentration addition and toxic index models. The model deviation ratios (MDR) ranged from 0.553 ± 0.024 to 1.096 ± 0.021 while the toxic index (TI) varied between 0.912 ± 0.017 and 1.810 ± 0.078. However, the MDR and TI for all mixtures lie between 0.5 and 2.0. Thus, the joint action of the mixtures were considered additive.

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Joint-action ecotoxicity of binary mixtures of glutaraldehyde and surfactants used in hospitals: Use of the Toxicity Index model and isoblogram representation

Cited by 49 publications

References 31 publications

Bactericidal Activity and Physiological Effects of Combined Application of Poly-Hexamethylene Biguanide Hydrochloride and 1-bromo-3-chloro-5, 5-dimethylimidazolidine-2, 4-dione on Staphylococcus aureus

Bactericidal Activity and Physiological Effects of Combined Application of Poly-Hexamethylene Biguanide Hydrochloride and 1-bromo-3-chloro-5, 5-dimethylimidazolidine-2, 4-dione on Staphylococcus aureus

A new effect residual ratio (ERR) method for the validation of the concentration addition and independent action models

Toxicity of Quaternary Mixtures of Phenolic Compounds and Formulated Glyphosate to Microbial Community of River Water

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