Jellyfish collagen scaffolds for cartilage tissue engineering

Hoyer, Birgit; Bernhardt, Anne; Lode, Anja; Heinemann, Sascha; Sewing, Judith; Klinger, Matthias; Notbohm, Holger; Gelinsky, Michael

doi:10.1016/j.actbio.2013.10.022

Cited by 155 publications

(128 citation statements)

References 57 publications

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“…Therefore, marine organism-derived materials have become initiators or co-initiators of hundreds of promising pharmaceutical and tissue-engineered skin substitutes [50]. Many studies based on marine organism-derived collagen scaffolds for skin tissue regeneration have demonstrated a high potential in clinical applications [51]. In this regard, a composite film comprising salmon milt DNA and salmon collagen showed a remarkable efficacy in wound regeneration [52].…”

Section: Marine Fish-derived Collagenmentioning

confidence: 99%

Marine Fish Proteins and Peptides for Cosmeceuticals: A Review

et al. 2017

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Marine fish provide a rich source of bioactive compounds such as proteins and peptides. The bioactive proteins and peptides derived from marine fish have gained enormous interest in nutraceutical, pharmaceutical, and cosmeceutical industries due to their broad spectrum of bioactivities, including antioxidant, antimicrobial, and anti-aging activities. Recently, the development of cosmeceuticals using marine fish-derived proteins and peptides obtained from chemical or enzymatical hydrolysis of fish processing by-products has increased rapidly owing to their activities in antioxidation and tissue regeneration. Marine fish-derived collagen has been utilized for the development of cosmeceutical products due to its abilities in skin repair and tissue regeneration. Marine fish-derived peptides have also been utilized for various cosmeceutical applications due to their antioxidant, antimicrobial, and matrix metalloproteinase inhibitory activities. In addition, marine fish-derived proteins and hydrolysates demonstrated efficient anti-photoaging activity. The present review highlights and presents an overview of the current status of the isolation and applications of marine fish-derived proteins and peptides. This review also demonstrates that marine fish-derived proteins and peptides have high potential for biocompatible and effective cosmeceuticals.

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Section: Marine Fish-derived Collagenmentioning

confidence: 99%

Marine Fish Proteins and Peptides for Cosmeceuticals: A Review

et al. 2017

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“…This result was in accordance with previous reports for collagen from bester sturgeon skin (Zhang et al, 2014b), suggesting that ions might bind to the regions with excess charge density and accelerate protein monomers register longitudinally to form fibrils. However, the fibril-forming rate and degree of collagen from salmon skin and jellyfish were suppressed by the addition of NaCl (Yunoki et al, 2004;Hoyer et al, 2014), indicating fibrillogenesis is highly sensitive to collagen sources, the experimental conditions and the disparity in structural information which encoded in primary sequences (Tang et al, 2015).…”

Section: Fibril-forming Ability In Vitromentioning

confidence: 99%

Physicochemical characteristics and fibril-forming properties of collagen from paddlefish (Polyodon spathula) and globefish (Fugu flavidus) skin byproducts

2017

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Acid-soluble collagen (ASC) and pepsin-soluble collagen (PSC) from the skin byproducts of paddlefish (ASC-P and PSC-P) and globefish (ASC-G and PSC-G) were purified and characterized. The imino acid contents of ASC-P, PSC-P, 197.9, 186.4 and 189.7 residues/1000 residues, respectively. SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and Fourier transform infrared spectroscopy (FTIR) confirmed that all four samples composed of two different α1-and α2-chains with integrated triple-helical structure. Denaturation temperatures of ASC-P, PSC-P, ASC-G and PSC-G were 29.6, 28.2, 27.4 and 26.9 °C, respectively. Based on Transmission electron microscopy (TEM) observation, all four samples could assemble into fibrils in vitro with D-periodicity. However, the fibril-forming rate of ASC-P and PSC-P was more rapid than that of ASC-G and PSC-G. Scanning electron microscopy (SEM) analysis confirmed well-defined fibril morphologies,the diameter of fibrils from ASC-P and PSC-P was thicker than those of ASC-G and PSC-G after 24 h incubation. These results indicated that paddlefish and globefish skin collagens could be alternatives to terrestrial collagens for applications in food-packaging, nutraceutical and pharmaceutical industries.Keywords: paddlefish; globefish; collagen; physicochemical property; fibril-forming property; fibril morphology.Practical Application: Utilization of paddlefish and globefish skin byproducts by extracting collagen with good physicochemical and fibril-forming properties.

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“…Moreover, recently a broad range of studies based on marine organism-obtained collagen scaffolds for skin tissue regeneration have been reported to have high potential in clinical applications [66]. Recently, a novel composite film comprising salmon milt DNA and salmon collagen was fabricated for wound dressing applications.…”

Section: Collagenmentioning

confidence: 99%